Based on studies in mice, the complex of MECP2, SIN3A and HDAC1 binds one of several alternative promoters of the brain-derived neurotrophic factor (BDNF) gene, the promoter in front of the BDNF exon IV (Martinowich et al. 2003). This promoter is homologous to the promoter in front of the rat Bdnf exon III, which was also shown to be occupied by Mecp2 (Chen et al. 2003).
West, AE, Greenberg, ME, Griffith, EC, Chen, WG, Jaenisch, R, Lin, Y, Meissner, A, Chang, Q
Fouse, S, Wu, H, Sun, YE, Fan, G, He, F, Martinowich, K, Hu, Y, Hattori, D
© 2023 Reactome
