Reactome | Intracellular signaling by second messengers

Intracellular signaling by second messengers

Stable Identifier

R-HSA-9006925

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Intracellular signaling by second messengers

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Second messengers are generated within the cell as a downstream step in signal transduction cascades initiated by the interaction of an external stimulus with a cell surface receptor. Common second messengers include DAG, cAMP, cGMP, IP3, Ca2+ and phosphatidylinositols (reviewed in Kang et al, 2015; Raker et al, 2016; Li and Marshall, 2015; Pinto et al, 2015; Ahmad et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
26588873	Roles of phosphoinositide-specific phospholipase Cγ1 in brain development Kim, S, Kang, DS, Lee, C, Suh, PG, Yang, YR, Ryu, SH	Adv Biol Regul	2016
26275497	Calcium signaling and cell proliferation Ulrich, H, Gomes, KN, Goulart, VA, Kihara, AH, Resende, RR, Pinto, MC, Tonelli, FM	Cell. Signal.	2015
27065076	The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases Becker, C, Steinbrink, K, Raker, VK	Front Immunol	2016
26922871	Signalling at membrane contact sites: two membranes come together to handle second messengers Patel, S, Levine, TP	Curr. Opin. Cell Biol.	2016
25056711	Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets Murata, T, Ahmad, F, Degerman, E, Shimizu, K, Manganiello, V, Maurice, D	Oral Dis	2015