Expression of the pro-apoptotic APAF1 gene is directly stimulated by E2F1 binding to the APAF1 promoter. E2F6 can compete with E2F1 for the E2F binding site in the APAF1 promoter. Binding of E2F6 to the APAF1 promoter represses APAF1 transcription, which is implicated in suppression of growth-associated apoptosis in human hematopoietic progenitor cells (Kikuchi et al. 2007).
Nakamura, M, Kikuchi, J, Ando, H, Furukawa, Y, Shimizu, R, Ozawa, K, Wada, T
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