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E2F6 binds APAF1 gene promoter
Stable Identifier
R-HSA-9007522
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
E2F6 binds APAF1 gene promoter (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
E2F6, presumably in complex with TFDP1 (DP-1) or TFDP2 (DP-2), binds to the promoter of the APAF1 gene (Kikuchi et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
17600109
E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1
Nakamura, M
,
Kikuchi, J
,
Ando, H
,
Furukawa, Y
,
Shimizu, R
,
Ozawa, K
,
Wada, T
Stem Cells
2007
Participants
Input
APAF1 gene [nucleoplasm]
(Homo sapiens)
E2F6:(TFDP1,TFDP2) [nucleoplasm]
(Homo sapiens)
Output
E2F6:(TFDP1,TFDP2):APAF1 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Transcriptional Regulation by E2F6 (Homo sapiens)
Authored
Orlic-Milacic, M (2017-06-01)
Reviewed
Herlihy, A (2017-05-12)
Created
Orlic-Milacic, M (2017-05-31)
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