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p-S12-E2F6 [nucleoplasm]
Stable Identifier
R-HSA-9007536
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
CHEK1 phosphorylates E2F6 (Homo sapiens)
p-S12-E2F6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75461 E2F6
Gene Names
E2F6
Chain
chain:1-281
Reference Genes
BioGPS Gene:1876 E2F6
COSMIC (genes):E2F6 E2F6
CTD Gene:1876 E2F6
dbSNP Gene:1876 E2F6
ENSEMBL:ENSG00000169016.17 E2F6
HGNC:3120 E2F6
KEGG Gene (Homo sapiens):1876 E2F6
Monarch:1876 E2F6
NCBI Gene:1876 E2F6
OMIM:602944 E2F6
UCSC:O75461 E2F6
Reference Transcript
RefSeq:NM_001278276.1 E2F6
RefSeq:NM_001278275.1 E2F6
RefSeq:NM_001278278.1 E2F6
RefSeq:NM_198256.3 E2F6
RefSeq:NM_001278277.1 E2F6
Other Identifiers
0000070170
11729233_a_at
11729234_at
11729235_s_at
11746243_x_at
11753235_s_at
16894539
1876
203957_PM_at
203957_at
2540583
2540584
2540585
2540586
2540587
2540590
2540593
2540594
2540595
2540596
2540597
2540598
2540599
2540601
2540602
2540603
35984_at
3936663
3936664
3936665
3936666
3936667
3936668
3938015
3938016
3938017
3938018
3938019
3938020
3953959
3953960
3953961
3953962
3953963
50412_at
8050336
A_23_P170774
A_32_P12610
A_32_P230720
A_32_P27271
A_33_P3416301
GE81093
GO:0000083
GO:0000122
GO:0000278
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001227
GO:0003677
GO:0003700
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0006351
GO:0006355
GO:0006357
GO:0007049
GO:0032991
GO:0043226
GO:0043565
GO:0046983
GO:0071339
GO:0090575
HMNXSV003021766
HMNXSV003050171
ILMN_1656196
ILMN_2309608
PH_hs_0031768
TC02001579.hg
TC02004051.hg
g12669917_3p_at
Participates
as an output of
CHEK1 phosphorylates E2F6 (Homo sapiens)
Other forms of this molecule
E2F6 [nucleoplasm]
Inferred To
phospho-E2f1 [nucleoplasm]
(Drosophila melanogaster)
phospho-e2f6 [nucleoplasm]
(Xenopus tropicalis)
phospho-E2f6 [nucleoplasm]
(Mus musculus)
phospho-E2f6 [nucleoplasm]
(Rattus norvegicus)
phospho-p-S12-E2F6 [nucleoplasm]
(Canis familiaris)
phospho-p-S12-E2F6 [nucleoplasm]
(Danio rerio)
phospho-p-S12-E2F6 [nucleoplasm]
(Dictyostelium discoideum)
phospho-E2F6 [nucleoplasm]
(Bos taurus)
phospho-E2F6 [nucleoplasm]
(Gallus gallus)
phospho-E2F6 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 12
Coordinate
12
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001265206.1
,
NP_001265204.1
,
NP_001265205.1
,
NP_001265207.1
,
NP_937987.2
OpenTargets
ENSG00000169016
GeneCards
O75461
HPA
ENSG00000169016-E2F6
Ensembl
ENST00000542100
,
ENSP00000446315
,
ENST00000381525
,
ENST00000307236
,
ENST00000546212
,
ENSG00000169016
,
ENSP00000370936
,
ENSP00000302159
,
ENSP00000438864
PRO
O75461
Pharos - Targets
O75461
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.949
22
UniProt:Q14188 TFDP2
1
TFDP2 [nucleoplasm]
(R-HSA-1362225)
0.874
9
UniProt:Q14188-5 TFDP2
0.735
11
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.659
3
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.643
4
UniProt:Q99496 RNF2
1
RNF2 [nucleoplasm]
(R-HSA-389119)
0.643
4
UniProt:P61244 MAX
1
MAX [nucleoplasm]
(R-HSA-3006627)
0.623
4
UniProt:P41229 KDM5C
1
KDM5C [nucleoplasm]
(R-HSA-4754186)
0.597
3
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.556
3
UniProt:Q9NX08 COMMD8
2
COMMD8 [nucleoplasm]
(R-HSA-8955102)
COMMD8 [cytosol]
(R-HSA-8955107)
0.527
2
UniProt:Q06587 RING1
1
RING1 [nucleoplasm]
(R-HSA-389113)
0.527
3
UniProt:Q8IWI9 MGA
1
MGA [nucleoplasm]
(R-HSA-8953093)
0.527
2
UniProt:Q8IY57 YAF2
1
YAF2 [nucleoplasm]
(R-HSA-8937973)
0.527
3
UniProt:Q8N668 COMMD1
2
COMMD1 [nucleoplasm]
(R-HSA-8955094)
COMMD1 [cytosol]
(R-HSA-8955110)
0.527
2
UniProt:Q9H0A8 COMMD4
2
COMMD4 [nucleoplasm]
(R-HSA-8955106)
COMMD4 [cytosol]
(R-HSA-8955111)
0.527
2
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.527
3
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.527
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.527
2
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.527
3
UniProt:Q969R5 L3MBTL2
2
L3MBTL2 [nucleoplasm]
(R-HSA-6804477)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(R-HSA-6804480)
0.527
3
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.488
2
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