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MSX2 [nucleoplasm]
Stable Identifier
R-HSA-9007760
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Homeobox protein MSX-2, HOX8, HOX-8
Locations in the PathwayBrowser for interactor UniProt:Q9BYJ9 YTHD1
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
MSX2 binds RUNX2 gene promoter (Homo sapiens)
MSX2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35548 MSX2
Gene Names
MSX2, HOX8
Chain
chain:1-267
Reference Genes
BioGPS Gene:4488 MSX2
COSMIC (genes):MSX2 MSX2
CTD Gene:4488 MSX2
dbSNP Gene:4488 MSX2
ENSEMBL:ENSG00000120149 MSX2
HGNC:7392 MSX2
KEGG:hsa:4488 MSX2
Monarch:4488 MSX2
NCBI Gene:4488 MSX2
OMIM:123101 MSX2
UCSC:P35548 MSX2
Reference Transcript
RefSeq:NM_002449.4 MSX2
Other Identifiers
11730340_x_at
11759030_a_at
16992622
205555_PM_s_at
205555_s_at
210319_3p_x_at
210319_PM_x_at
210319_x_at
2841966
2841967
2841968
2841970
2841971
2841972
2841973
2841974
2841975
3728612
3728620
3728622
40733_f_at
40734_r_at
4488
8110084
A_24_P132006
A_24_P132008
D89377_at
D89377_s_at
GE58290
GO:0000122
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001227
GO:0001503
GO:0001649
GO:0002063
GO:0002076
GO:0003148
GO:0003151
GO:0003161
GO:0003198
GO:0003416
GO:0003677
GO:0005515
GO:0005634
GO:0005667
GO:0005829
GO:0006355
GO:0006357
GO:0008285
GO:0009952
GO:0012501
GO:0016607
GO:0023019
GO:0030154
GO:0030326
GO:0030509
GO:0030513
GO:0035115
GO:0035116
GO:0035313
GO:0035880
GO:0042060
GO:0042476
GO:0042733
GO:0042981
GO:0043066
GO:0043226
GO:0043565
GO:0045599
GO:0045617
GO:0045669
GO:0045892
GO:0048598
GO:0048856
GO:0048863
GO:0048870
GO:0051216
GO:0051795
GO:0060346
GO:0060349
GO:0060363
GO:0060364
GO:0060444
GO:0061180
GO:0061311
GO:0070166
GO:0071363
GO:0071392
GO:0090427
GO:0097152
GO:0140110
GO:1990837
GO:2001055
HMNXSV003012723
ILMN_1766951
PH_hs_0004979
TC05000974.hg
g1321637_3p_a_at
g1722693_3p_a_at
g1722693_3p_x_at
g6996018_3p_a_at
Participates
as an input of
MSX2 binds RUNX2 gene promoter (Homo sapiens)
as a component of
MSX2:RUNX2 gene [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
NP_002440.2
OpenTargets
ENSG00000120149
ENSEMBL
ENSP00000239243
,
ENST00000239243
HPA
ENSG00000120149-MSX2
PRO
P35548
Pharos - Targets
P35548
Orphanet
MSX2
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01974 ROR2
2
ROR2 [plasma membrane]
(R-HSA-197731)
ROR2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5140729)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
12
UniProt:Q9H0E2 TOLLIP
4
TOLLIP [cytosol]
(R-HSA-446885)
TOLLIP [specific granule lumen]
(R-HSA-6799719)
TOLLIP [extracellular region]
(R-HSA-6800448)
TOLLIP [azurophil granule lumen]
(R-HSA-6799709)
0.556
3
UniProt:O75593 FOXH1
1
FOXH1 [nucleoplasm]
(R-HSA-1225914)
0.556
3
UniProt:P23769 GATA2
1
GATA2 [nucleoplasm]
(R-HSA-996735)
0.556
3
IntAct:EBI-25865403 EHD27213144
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q9HBE1-4 PATZ1
0.556
3
UniProt:Q9NQB0-10 TCF7L2
0.556
3
UniProt:P35711-4 SOX5
0.556
3
UniProt:Q08117-2 TLE5
0.556
3
UniProt:P78337 PITX1
0.556
3
UniProt:Q14119 VEZF1
0.556
3
UniProt:Q86WV8 Q86WV8
0.556
3
UniProt:O95833 CLIC3
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:Q68D86 C102B
0.556
3
UniProt:P28482 MAPK1
18
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
MAPK1 [cytosol]
(R-HSA-59282)
MAPK1 [nucleoplasm]
(R-HSA-199960)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
0.556
3
IntAct:EBI-22320186 CCSB ORF ID
0.556
3
UniProt:P09086-4 POU2F2
0.556
3
UniProt:P31274 HXC9
0.556
3
UniProt:O15197-2 EPHB6
0.556
3
UniProt:O43711 TLX3
0.556
3
UniProt:P28069 PIT1
0.556
3
UniProt:Q96K80 ZC3HA
0.556
3
UniProt:P78424 PO6F2
0.556
3
UniProt:Q96HR8 NAF1
0.556
3
UniProt:Q6ZRY4 RBPS2
0.556
3
UniProt:Q9NZ81 PRR13
0.556
3
UniProt:Q96PV6 LENG8
0.556
3
UniProt:Q8NEK8 TET5D
0.556
3
UniProt:Q9BQY4 RHXF2
0.556
3
UniProt:Q15911-2 ZFHX3
0.556
3
UniProt:Q8WU79 SMAP2
0.556
3
UniProt:Q8NDC0 MISSL
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q9BYJ9 YTHD1
0.556
3
UniProt:Q96PN8 TSSK3
0.556
3
UniProt:Q6AI12 ANR40
0.527
2
UniProt:Q9H7S9 ZNF703
1
ZNF703 [nucleoplasm]
(R-HSA-2454149)
0.527
2
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