WWP1 polyubiquitinates RUNX2

Stable Identifier
R-HSA-9008076
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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WWP1 polyubiquitinates RUNX2
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Studies in mice have shown that once HIVEP3 (SHN3, Schnurri-3) and WWP1 are bound to RUNX2, WWP1, an E3 ubiquitin ligase, polyubiquitinates RUNX2, targeting it for proteasome-mediated degradation. HIVEP3 overexpression in human embryonic kidney 293T cells leads to a dose-dependent decrease in RUNX2 protein levels (Jones et al. 2006).
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Catalyst Activity

ubiquitin protein ligase activity of RUNX2:HIVEP3:WWP1 [cytosol]

Physical Entity
RUNX2:HIVEP3:WWP1 [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Inferred From
Wwp1 polyubiquitinates Runx2 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-07)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-07)
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