Proteasome degrades polyubiquitinated RUNX2

Stable Identifier
R-HSA-9008475
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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RUNX2, polyubiquitinated by FBXW7alpha in a GSK3B-dependant manner, is degraded by the proteasome (Kumar et al. 2015).

Literature References
PubMed ID Title Journal Year
26542806 E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation

Kumar, Y, Kapoor, I, Khan, K, Thacker, G, Khan, MP, Shukla, N, Kanaujiya, JK, Sanyal, S, Chattopadhyay, N, Trivedi, AK

J. Biol. Chem. 2015
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Participates
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

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