IL37:IL18R1 binds SIGIRR

Stable Identifier
Reaction [binding]
Homo sapiens
IL-37:IL-18R1 binds SIGIRR
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Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL-37, IL-1 F7) is a member of the IL-1 family. There are five isoforms of IL-37 (a-e) of which transcript IL-37b is known to be functional (Sharma et al. 2008). This isoform is represented in UniProt as the canonical form of IL-37 and in Reactome as the full length, unprocessed form of IL-37. IL-37 can bind the Interleukin-18 receptor 1 (IL-18R1) (Shi et al. 2003, Kumar et al. 2002). Upon binding to IL-18R1, IL-37 facilitates the recruitment of Single Ig IL 1 related receptor (SIGIRR, TIR-8, IL-1R8) forming a complex (Nold Petry et al. 2015). These events ultimately lead to suppression of cytokine production in several types of immune cells resulting in reduced inflammation.
Literature References
PubMed ID Title Journal Year
25729923 IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

Lotz-Havla, AS, Dinarello, CA, Li, S, Rossello, FJ, Garlanda, C, Gersting, SW, Nold, MF, Rudloff, I, Bufler, P, Lo, CY, Azam, T, Lao, JC, Cho, SX, Gantier, MP, Mantovani, A, Elgass, KD, Whisstock, JC, Rotter, B, Nold-Petry, CA, Ellisdon, AM, Mangan, NE

Nat. Immunol. 2015
Orthologous Events
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