BAX gene expression is stimulated by RUNX2

Stable Identifier
Reaction [omitted]
Homo sapiens
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BAX gene transcription is directly stimulated by binding of RUNX2, presumably in complex with CBFB, to RUNX2 response elements in the BAX promoter (Eliseev et al. 2008, Goloudina, Tanoue et al. 2012, Goloudina, Mazur et al. 2012).

Literature References
PubMed ID Title Journal Year
22065775 Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents

Goloudina, AR, Tanoue, K, Hammann, A, Fourmaux, E, le Guezennec, X, Bulavin, DV, Mazur, SJ, Appella, E, Garrido, C, Demidov, ON

Proc. Natl. Acad. Sci. U.S.A. 2012
18223689 Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis

Eliseev, RA, Dong, YF, Sampson, E, Zuscik, MJ, Schwarz, EM, O'Keefe, RJ, Rosier, RN, Drissi, MH

Oncogene 2008
22544321 Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio

Goloudina, AR, Mazur, SJ, Appella, E, Garrido, C, Demidov, ON

Cell Cycle 2012
This event is regulated
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