Reactome | PTPN12 [nucleoplasm]

PTPN12 [nucleoplasm]

Stable Identifier

R-HSA-9008905

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PTP-PEST, Tyrosine-protein phosphatase non-receptor type 12, PTN12_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-37 signaling (Homo sapiens)
        
        PTPNs gene transcription and translation (Homo sapiens)
        
        PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23 [nucleoplasm] (Homo sapiens)
        
        PTPN12 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q05209 PTPN12

Gene Names

PTPN12

Chain

chain:1-780

Reference Genes

BioGPS Gene:5782 PTPN12

COSMIC (genes):PTPN12 PTPN12

CTD Gene:5782 PTPN12

dbSNP Gene:5782 PTPN12

ENSEMBL:ENSG00000127947 PTPN12

HGNC:9645 PTPN12

KEGG:hsa:5782 PTPN12

Monarch:5782 PTPN12

NCBI Gene:5782 PTPN12

OMIM:600079 PTPN12

UCSC:Q05209 PTPN12

Reference Transcript

Other Identifiers

11717887_s_at

11732037_a_at

11740181_a_at

1463_at

17047652

202006_PM_at

202006_at

216915_PM_s_at

216915_s_at

3009960

3009961

3009962

3009963

3009964

3009965

3009976

3009977

3009979

3009980

3009981

3009982

3009983

3009985

3009986

3009987

3009991

3009992

3009993

3009995

3009996

3009997

3009999

3010004

3010007

3010009

3010010

3010012

3010013

3010014

3010015

3010016

5782

8133788

A_14_P126061

A_23_P8763

GE58151

GO:0002102

GO:0003824

GO:0004721

GO:0004725

GO:0004726

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005925

GO:0006470

GO:0016311

GO:0016787

GO:0017124

GO:0035335

GO:0042058

GO:0042246

GO:0042995

GO:0043226

GO:0043229

GO:0048856

GO:0070161

GO:0071364

GO:0140096

GO:1901185

GO:2000587

HMNXSV003039324

Hs.62.1.S1_3p_a_at

ILMN_1695509

ILMN_2222074

M93425_at

PH_hs_0000009

TC07000495.hg

TC07002426.hg

g4506286_3p_at

Participates

as a member of

PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PTPN12 [cytosol]

Cross References

RefSeq

NP_002826.3, NP_001124481.1, NP_001124480.1

OpenTargets

ENSG00000127947

ENSEMBL

ENST00000435495, ENSP00000392429, ENSP00000248594, ENSP00000397991, ENST00000415482, ENST00000248594

ZINC - Substances

PTN12_HUMAN

ZINC target

Q05209

PRO

Q05209

GlyGen

Q05209

PDB

5J8R, 5O2P, 5HDE

IntEnz

3.1.3.48

HPA

ENSG00000127947-PTPN12

Pharos - Targets

Q05209

ZINC - Predictions - Purchasable

PTN12_HUMAN

HMDB Protein

HMDBP08927

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.856	9
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.835	9
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.807	5
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.762	4
UniProt:Q9H939 PPIP2			0.745	6
UniProt:P09619 PDGFRB	3	p-12Y-PDGFRB [plasma membrane] (R-HSA-186803) PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039)	0.704	3
UniProt:P56945 BCAR1	4	BCAR1 [cytosol] (R-HSA-201625) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645)	0.691	5
UniProt:P42768 WAS	2	p-Y291-WAS [cytosol] (R-HSA-2197668) WAS [cytosol] (R-HSA-201879)	0.609	2
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.592	4
UniProt:P29350 PTPN6	5	PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.564	3
UniProt:O60711 LPXN			0.527	3
UniProt:Q9P0L0 VAPA	4	VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920)	0.527	3

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