Reactome | PTPN5 [nucleoplasm]

PTPN5 [nucleoplasm]

Stable Identifier

R-HSA-9008908

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-37 signaling (Homo sapiens)
        
        PTPNs gene transcription and translation (Homo sapiens)
        
        PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23 [nucleoplasm] (Homo sapiens)
        
        PTPN5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P54829 PTPN5

Gene Names

PTPN5

Chain

chain:1-565

Reference Genes

BioGPS Gene:84867 PTPN5

COSMIC (genes):PTPN5 PTPN5

CTD Gene:84867 PTPN5

dbSNP Gene:84867 PTPN5

ENSEMBL:ENSG00000110786 PTPN5

HGNC:9657 PTPN5

KEGG:hsa:84867 PTPN5

Monarch:84867 PTPN5

NCBI Gene:84867 PTPN5

OMIM:176879 PTPN5

UCSC:P54829 PTPN5

Reference Transcript

Other Identifiers

11727446_a_at

11747403_a_at

11750810_a_at

16736595

233471_PM_at

233471_at

236456_PM_at

236456_at

2536619

3365602

3365603

3365604

3365605

3365606

3365607

3365608

3365611

3365613

3365615

3365616

3365617

3365618

3365619

3365621

3365623

3365624

3365625

3365626

3365627

3365628

3365631

3365633

3365634

3365638

3365639

3365640

3365641

3365642

3365643

3365644

3365645

3365646

47884_at

7947076

84867

A_24_P409519

GE59045

GO:0001784

GO:0003824

GO:0004721

GO:0004725

GO:0005515

GO:0005654

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006470

GO:0007165

GO:0016020

GO:0016311

GO:0016787

GO:0019901

GO:0030054

GO:0043226

GO:0140096

HMNXSV003017088

HMNXSV003023187

Hs.248318.0.S1_3p_at

Hs.79092.0.A1_3p_at

ILMN_1781073

ILMN_2363966

PH_hs_0004569

TC11001472.hg

U27831_at

Participates

as a member of

PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001035059.1, NP_008837.1, NP_116170.3, NP_001265168.1, NP_001265167.1, NP_001265165.1

OpenTargets

ENSG00000110786

ENSEMBL

ENSP00000379473, ENST00000396170, ENSP00000379471, ENST00000358540, ENST00000396168, ENSP00000351342

HPA

ENSG00000110786-PTPN5

ZINC - Substances

PTN5_HUMAN

ZINC target

P54829

PRO

P54829

Pharos - Targets

P54829

ZINC - Predictions - Purchasable

PTN5_HUMAN

PDB

5OVR, 5OVX, 8SLU, 6H8R, 5OW1, 8SLT, 8SLS, 2BIJ, 2BV5, 2CJZ

HMDB Protein

HMDBP08937

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27361 MAPK3	6	p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) MAPK3 [cytosol] (R-HSA-59284) MAPK3 [nucleoplasm] (R-HSA-73724) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295)	0.643	3
UniProt:P28482 MAPK1	18	p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185-MAPK1 [cytosol] (R-HSA-9635773) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293)	0.643	3

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