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PTPN6 [nucleoplasm]
Stable Identifier
R-HSA-9008911
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SHP1, SHP-1, Src homology phosphatase-1, Protein-tyrosine phosphatase, non-receptor type 6, PTN6_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-37 signaling (Homo sapiens)
PTPNs gene transcription and translation (Homo sapiens)
PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23 [nucleoplasm] (Homo sapiens)
PTPN6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29350 PTPN6
Gene Names
PTPN6, HCP, PTP1C
Chain
chain:1-595
Reference Genes
BioGPS Gene:5777 PTPN6
COSMIC (genes):PTPN6 PTPN6
CTD Gene:5777 PTPN6
dbSNP Gene:5777 PTPN6
ENSEMBL:ENSG00000111679 PTPN6
ENSEMBL_homo_sapiens_GENE:ENSG00000111679.17 PTPN6
HGNC:9658 PTPN6
KEGG Gene (Homo sapiens):5777 PTPN6
Monarch:5777 PTPN6
NCBI Gene:5777 PTPN6
OMIM:176883 PTPN6
UCSC:P29350 PTPN6
Reference Transcript
RefSeq:NM_002831.5 PTPN6
RefSeq:NM_080548.4 PTPN6
RefSeq:NM_080549.3 PTPN6
RefSeq:XM_011520988.1 PTPN6
Other Identifiers
11726034_a_at
11739054_a_at
11739055_x_at
16747623
206687_PM_s_at
206687_s_at
3403093
3403095
3403096
3403097
3403099
3403102
3403106
3403107
3403108
3403109
3403110
3403111
3403113
3403114
3403117
3403118
3403119
3403120
3403121
3403122
3403123
5777
794_at
7953569
A_23_P162486
GE59877
GO:0000165
GO:0000278
GO:0001784
GO:0002244
GO:0002376
GO:0002924
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005001
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006470
GO:0006954
GO:0007155
GO:0007186
GO:0008284
GO:0008285
GO:0012501
GO:0016020
GO:0016311
GO:0016787
GO:0016791
GO:0017124
GO:0018108
GO:0019221
GO:0019901
GO:0023052
GO:0030154
GO:0030220
GO:0031295
GO:0031410
GO:0032715
GO:0032720
GO:0032991
GO:0033007
GO:0033630
GO:0035335
GO:0035556
GO:0035580
GO:0035855
GO:0036211
GO:0042060
GO:0042098
GO:0042105
GO:0042130
GO:0042169
GO:0042267
GO:0042981
GO:0043226
GO:0043409
GO:0045577
GO:0048856
GO:0050732
GO:0050839
GO:0050852
GO:0050853
GO:0050860
GO:0051279
GO:0051897
GO:0055065
GO:0055085
GO:0060089
GO:0060338
GO:0070062
GO:0070372
GO:0070527
GO:0071310
GO:0098542
GO:0106015
GO:0140031
GO:0140096
GO:1904724
GO:1905867
GO:2000045
HMNXSV003044817
ILMN_1664122
ILMN_1716578
ILMN_1738675
PH_hs_0003980
TC12000101.hg
X62055_at
g4506296_3p_a_at
Participates
as a member of
PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PTPN6 [specific granule lumen]
PTPN6 [extracellular region]
PTPN6 [tertiary granule lumen]
PTPN6 [cytosol]
Cross References
RefSeq
NP_002822.2
,
NP_536858.1
,
XP_011519290.1
,
NP_536859.1
OpenTargets
ENSG00000111679
ZINC - Substances
PTN6_HUMAN
ZINC target
P29350
ZINC - Biogenic
PTN6_HUMAN
PRO
P29350
PDB
6SM5
,
4GRZ
,
2YU7
,
8YHI
,
4GRY
,
4GS0
,
4HJQ
,
1FPR
,
3PS5
,
2RMX
,
1X6C
,
1GWZ
,
4HJP
,
2B3O
IntEnz
3.1.3.48
GeneCards
P29350
HPA
ENSG00000111679-PTPN6
Ensembl
ENST00000399448
,
ENST00000456013
,
ENSP00000391592
,
ENST00000318974
,
ENSG00000111679
,
ENSP00000326010
,
ENSP00000382376
Pharos - Targets
P29350
ZINC - Predictions - Purchasable
PTN6_HUMAN
HMDB Protein
HMDBP02499
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43628 KIR2DL3
1
KIR2DL3 [plasma membrane]
(R-HSA-3006532)
0.824
13
UniProt:P20138 CD33
3
CD33 [tertiary granule membrane]
(R-HSA-6800959)
CD33 [plasma membrane]
(R-HSA-197719)
CD33 [specific granule membrane]
(R-HSA-6799615)
0.824
10
UniProt:P19235 EPOR
2
EPOR [plasma membrane]
(R-HSA-1168347)
p-8Y-EPOR [plasma membrane]
(R-HSA-9006274)
0.8
11
UniProt:P31994 FCGR2B
1
FCGR2B [plasma membrane]
(R-HSA-197854)
0.669
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.646
3
UniProt:P08922 ROS1
0.642
4
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.623
5
UniProt:Q6GTX8 LAIR1
3
LAIR1 [specific granule membrane]
(R-HSA-6799644)
LAIR1 [plasma membrane]
(R-HSA-5686426)
LAIR1 [tertiary granule membrane]
(R-HSA-6800947)
0.613
5
UniProt:O94916-1 NFAT5
0.602
4
UniProt:Q9UKJ1 PILRA
1
PILRA [plasma membrane]
(R-HSA-3008978)
0.581
5
UniProt:P35968 KDR
5
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.573
2
UniProt:B7UM99 TIR
0.571
4
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.564
3
UniProt:Q9BZW8 CD244
1
CD244 [plasma membrane]
(R-HSA-197846)
0.564
2
UniProt:Q13643 FHL3
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.547
2
UniProt:P24394 IL4R
2
IL4R [plasma membrane]
(R-HSA-449670)
p-Y-IL4R [plasma membrane]
(R-HSA-6786087)
0.527
2
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.524
3
UniProt:P08069 IGF1R
3
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.508
3
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
0.499
2
UniProt:O35274 NEB2
0.499
2
UniProt:P11049 CD37
0.499
4
UniProt:P20273 CD22
3
NAc-CD22 [plasma membrane]
(R-HSA-5690736)
CD22 [plasma membrane]
(R-HSA-197703)
p-Y762,807,822-CD22 [plasma membrane]
(R-HSA-5690726)
0.499
4
UniProt:Q8N1K5 THMS1
0.499
4
UniProt:P32927 CSF2RB
6
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
CSF2RB [plasma membrane]
(R-HSA-879960)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
0.471
2
UniProt:P43626 KIR2DL1
1
KIR2DL1 [plasma membrane]
(R-HSA-199538)
0.462
4
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.462
2
UniProt:P78314 3BP2
0.462
2
UniProt:P16284 PECAM1
5
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
0.462
4
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