IL34:CSF1 binds CSF1R

Stable Identifier
R-HSA-9009485
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Interleukin-34 (IL34) can bind Macrophage colony-stimulating factor 1 (CSF1). The IL34:CSF1 heteromer may bind Macrophage colony-stimulating factor 1 receptor (CSF1R) facilitating receptor maturation and cellular trafficking. Consequently, downstream signaling pathways are activated (Segaliny et al. 2015). Ultimately, these events lead to the release of pro-inflammatory chemokines regulating the innate immunity and inflammation. The exact binding mechanism of IL34:CSF1 to CSF1R is unclear. Hence, this interaction is represented as a black box event.
Literature References
PubMed ID Title Journal Year
26095744 IL-34 and M-CSF form a novel heteromeric cytokine and regulate the M-CSF receptor activation and localization

Ségaliny, AI, Brulin, B, Téletchéa, S, Maillasson, M, Charrier, C, Heymann, D, Brion, R

Cytokine 2015
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!