Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
APH1B [endosome membrane]
Stable Identifier
R-HSA-9010060
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
APH-1B
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713) (Homo sapiens)
gamma-secretase complex [endosome membrane] (Homo sapiens)
APH1 [endosome membrane] (Homo sapiens)
APH1B [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WW43 APH1B
Gene Names
APH1B, PSFL, UNQ688/PRO1328
Chain
chain:1-257
Reference Genes
BioGPS Gene:83464 APH1B
COSMIC (genes):APH1B APH1B
CTD Gene:83464 APH1B
dbSNP Gene:83464 APH1B
ENSEMBL:ENSG00000138613 APH1B
ENSEMBL:ENSG00000138613.14 APH1B
HGNC:24080 APH1B
KEGG Gene (Homo sapiens):83464 APH1B
Monarch:83464 APH1B
NCBI Gene:83464 APH1B
OMIM:607630 APH1B
UCSC:Q8WW43 APH1B
Reference Transcript
RefSeq:NM_001145646.1 APH1B
RefSeq:NM_031301.3 APH1B
Other Identifiers
11720067_a_at
11720068_a_at
11740601_a_at
11740602_s_at
11740603_a_at
11756680_a_at
16801862
221036_PM_s_at
221036_s_at
226358_PM_at
226358_at
3010811
3597527
3597528
3597530
3597533
3597537
3597539
3597540
3597541
3597542
3597544
3597545
3597547
62125_at
65643_at
7984124
83464
91572_at
A_14_P102504
A_23_P205997
GE86938
GO:0005515
GO:0005768
GO:0005783
GO:0005886
GO:0007219
GO:0007220
GO:0010008
GO:0010950
GO:0016020
GO:0016485
GO:0023052
GO:0030133
GO:0030674
GO:0031293
GO:0031410
GO:0034205
GO:0042987
GO:0043085
GO:0043226
GO:0051604
GO:0060090
GO:0061133
GO:0070765
GO:0098772
HMNXSV003003928
Hs.29894.0.A1_3p_at
ILMN_1767816
ILMN_1862217
PH_hs_0003138
PH_hs_0034630
TC15000582.hg
g13775223_3p_s_at
Participates
as a member of
APH1 [endosome membrane] (Homo sapiens)
Other forms of this molecule
APH1B [plasma membrane]
Cross References
RefSeq
NP_001139118.1
,
NP_112591.2
OpenTargets
ENSG00000138613
HPA
ENSG00000138613-APH1B
GeneCards
Q8WW43
Ensembl
ENSG00000138613
,
ENST00000261879
,
ENSP00000369700
,
ENSP00000261879
,
ENST00000380343
PRO
Q8WW43
Pharos - Targets
Q8WW43
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text