Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)

Stable Identifier
R-HSA-9010096
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endosome membrane, endosome lumen
Synonyms
Gamma secretase cleaves APPs-beta to Abeta-40 and Abeta-42
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Beta secretase 1 (BACE1) catalyses the cleavage of APP(18 770) within the ectodomain and liberates a soluble proteolytic fragment, termed soluble APP beta (APPs beta, APP(18 671)) (Parvathy et al. 1999, Kinoshita et al. 2003). APPs beta is subsequently cleaved by the presenilin (PS) containing gamma secretase complex to eventually (step wise details of multiple cleavages not shown here) liberate the neurotoxic Abeta peptides 42 and 40 (APP(672 713) and APP(672 711) respectively) (Huse et al. 2002, Ehehalt et al. 2003, Anderson et al. 2005, Fukumori et al. 2006, Takami et al. 2009, Andrew et al. 2016).

Literature References
PubMed ID Title Journal Year
19828817 gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment

Sano, Y, Funamoto, S, Morishima-Kawashima, M, Ihara, Y, Nagashima, Y, Takami, M, Ishihara, S

J. Neurosci. 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of gamma-secretase complex [endosome membrane]

Physical Entity
gamma-secretase complex [endosome membrane] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Authored
Jassal, B  (2017-06-26)
Reviewed
Meras-Rios, A  (2018-08-10)
Created
Jassal, B  (2017-06-26)
Cite Us!