Reactome | NELL2 [extracellular region]

NELL2 [extracellular region]

Stable Identifier

R-HSA-9010198

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Icon

Locations in the PathwayBrowser for interactor UniProt:O00411 POLRMT

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of commissural axon pathfinding by SLIT and ROBO (Homo sapiens)
        
        ROBO3 binds NELL2 (Homo sapiens)
        
        NELL2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99435 NELL2

Gene Names

NELL2, NRP2

Chain

signal peptide:1-21, chain:22-816

Reference Genes

BioGPS Gene:4753 NELL2

COSMIC (genes):NELL2 NELL2

CTD Gene:4753 NELL2

dbSNP Gene:4753 NELL2

ENSEMBL:ENSG00000184613 NELL2

ENSEMBL_homo_sapiens_GENE:ENSG00000184613.11 NELL2

HGNC:7751 NELL2

KEGG Gene (Homo sapiens):4753 NELL2

Monarch:4753 NELL2

NCBI Gene:4753 NELL2

OMIM:602320 NELL2

UCSC:Q99435 NELL2

Reference Transcript

Other Identifiers

11720910_a_at

11740910_a_at

11747436_a_at

16763410

203413_PM_at

203413_at

32598_at

3451832

3451833

3451835

3451837

3451838

3451840

3451841

3451843

3451858

3451859

3451868

3451874

3451875

3451876

3451877

3451885

3451886

3451887

3451888

3451889

3451890

3451891

3451897

3451908

3451910

3451912

3451913

3451914

3451915

3451916

4753

7962455

A_23_P10025

D83018_at

GE57326

GO:0005080

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0007399

GO:0008201

GO:0009566

GO:0022414

GO:0030154

GO:0042802

GO:0048856

GO:0070050

GO:0071679

HMNXSV003027264

ILMN_1725417

PH_hs_0004598

TC12001415.hg

g5453765_3p_at

Participates

as a component of

NELL2:ROBO3 [plasma membrane] (Homo sapiens)

as an input of

ROBO3 binds NELL2 (Homo sapiens)

Cross References

RefSeq

NP_006150.1, XP_011536698.1, XP_005268962.1, NP_001138582.1, NP_001138580.1, NP_001138581.1, NP_001138579.1

OpenTargets

ENSG00000184613

GeneCards

Q99435

HPA

ENSG00000184613-NELL2

Ensembl

ENSP00000416341, ENSP00000447927, ENST00000395487, ENSG00000184613, ENSP00000378866, ENSP00000394612, ENST00000452445, ENST00000429094, ENST00000437801, ENSP00000327988, ENSP00000390680, ENST00000549027, ENST00000333837

PRO

Q99435

Pharos - Targets

Q99435

Orphanet

29812

PDB

6POG

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IZC7 ZNF101	1	ZNF101 [nucleoplasm] (R-HSA-975009)	0.527	2
UniProt:Q9BXX0 EMILIN2	1	EMILIN2 [extracellular region] (R-HSA-2161394)	0.527	2
UniProt:Q7L945 ZNF627	1	ZNF627 [nucleoplasm] (R-HSA-2127594)	0.527	2
UniProt:Q9NUA8 ZBT40			0.527	2
UniProt:Q9UHF1 EGFL7			0.527	2
UniProt:Q8NBT0 POC1A			0.527	2
UniProt:Q9UII2 ATIF1			0.527	2
UniProt:Q96C00 ZBTB9			0.527	2
UniProt:Q8TC44 POC1B			0.527	2
UniProt:Q92626 PXDN	1	PXDN [extracellular region] (R-HSA-2559628)	0.527	2
UniProt:Q8N8Y5 ZFP41			0.527	2
UniProt:Q9H9D4 ZN408			0.527	2
UniProt:Q86Y91 KIF18B	1	KIF18B [cytosol] (R-HSA-8849372)	0.527	2
UniProt:Q12797 ASPH	2	ASPH [endoplasmic reticulum lumen] (R-HSA-9631383) ASPH [endoplasmic reticulum membrane] (R-HSA-5490331)	0.527	2
UniProt:Q2NKJ3 CTC1	1	CTC1 [nucleoplasm] (R-HSA-9668825)	0.527	2
UniProt:Q6IPR3 TYW3	1	TYW3 [cytoplasm] (R-HSA-6782888)	0.527	2
UniProt:O00411 POLRMT	1	POLRMT [mitochondrial matrix] (R-HSA-163267)	0.527	2
UniProt:P31146 CORO1A	1	CORO1A [cytosol] (R-HSA-9636432)	0.527	2
UniProt:P23760 PAX3	2	PAX3 [nucleoplasm] (R-HSA-9757859) PAX3 (1-319) [nucleoplasm] (R-HSA-5603237)	0.527	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:Q7Z417 NUFP2			0.508	2
UniProt:Q5VTD9 GFI1B			0.508	2
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.508	2
UniProt:Q9UIS9 MBD1	2	monoSUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331) MBD1 [nucleoplasm] (R-HSA-417134)	0.508	2

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