Reactome | Calnexin/calreticulin cycle

Calnexin/calreticulin cycle

Stable Identifier

R-HSA-901042

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The unfolded protein is recognized by a chaperon protein (calnexin or calreticulin) and the folding process starts. The binding of these protein requires a mono-glucosylated glycan (Caramelo JJ and Parodi AJ, 2008) and lectin-based interaction with client proteins is the predominant contributor to chaperone activity of calreticulin (inferred from the mouse homolog in Lum et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
27413183	Contributions of the Lectin and Polypeptide Binding Sites of Calreticulin to Its Chaperone Functions in Vitro and in Cells Kozlov, G, Lum, R, Chapman, DC, Hong, SJ, Williams, DB, Ahmad, S	J Biol Chem	2016
18303019	Getting in and out from calnexin/calreticulin cycles Parodi, AJ, Caramelo, JJ	J Biol Chem	2008