The unfolded protein is recognized by a chaperon protein (calnexin or calreticulin) and the folding process starts. The binding of these protein requires a mono-glucosylated glycan (Caramelo JJ and Parodi AJ, 2008), but in certain cases can occur even in the absence of glycosylation (Ireland BS et al, 2008).
Howe, CM, Brockmeier, U, Williams, DB, Elliott, T, Ireland, BS
Parodi, AJ, Caramelo, JJ
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