kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]

Stable Identifier
R-HSA-901097
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CCBL2 (KAT 3) catalyzes the reaction of kynurenine and pyruvate to form 4-(2-aminophenyl)-2,4-dioxobutanoate and alanine. CCBL2 is known only as the predicted protein product of a cloned human gene closely homologous to CCBL1 (Yu et al. 2006) and all of the structural and catalytic properties annotated here are inferred from those of CCBL1.
Literature References
PubMed ID Title Journal Year
16376499 Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family

Cai, T, Zhang, L, Tagle, DA, Yu, P, Li, Z

Gene 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

kynurenine-oxoglutarate transaminase activity of CCBL2 dimer [cytosol]

Physical Entity
CCBL2 dimer [cytosol] (Homo sapiens)
Activity
kynurenine-oxoglutarate transaminase activity (GO:0016212)
Inferred From
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Homo sapiens)
Cross References
Rhea
Authored
D'Eustachio, P  (2010-07-02)
Reviewed
Jassal, B  (2010-11-09)
Created
D'Eustachio, P  (2010-07-02)
Cite Us!