Estrogen-responsive BCL2 gene expression

Stable Identifier
R-HSA-9011941
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Estrogen-responsive BCL2 gene expression
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ESR1 and HIST1H2AC contribute to estrogen-responsive transcriptional activation at the BCL and MYC genes by promoting long-range chromatin loops between enhancer elements. This is accompanied by the recruitment of EP300 and RNA polymerase II (Su et al, 2014).
Literature References
PubMed ID Title Journal Year
24371278 An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells

Hsu, MT, Tzeng, TY, Cheng, C, Su, CH

Nucleic Acids Res. 2014
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This event is regulated
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Regulator
BLC2 gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300 [nucleoplasm] (Homo sapiens)
Authored
Rothfels, K  (2017-09-29)
Reviewed
Magnani, L  (2018-02-23)
Created
Rothfels, K  (2017-07-07)
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