p-TEFb phosphorylates serine 2 in RNA polymerase II CTD

Stable Identifier
R-HSA-9012319
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-TEFb phosphorylates serine 2 in RNA polymerase II CTD
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Transcriptional pausing at the SL-dT site in the MYB gene is overcome in response to estrogen by the P-TEFb-mediated phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II (Drabsch et al, 2007; Mitra et al, 2012).

Literature References
PubMed ID Title Journal Year
17690249 Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells

Barry, SC, Miao, YR, Drabsch, Y, Gonda, TJ, Dowhan, DH, Ramsay, RG, Gewirtz, AM, Hugo, H, Zhang, R

Proc. Natl. Acad. Sci. U.S.A. 2007
22492511 Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene

Pereira, LA, Drabsch, Y, Mitra, P, Gonda, TJ, Ramsay, RG

Nucleic Acids Res. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm]

Physical Entity
MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Bos taurus)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Caenorhabditis elegans)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Canis familiaris)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Danio rerio)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Dictyostelium discoideum)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Drosophila melanogaster)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Gallus gallus)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Mus musculus)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Rattus norvegicus)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Saccharomyces cerevisiae)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Schizosaccharomyces pombe)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Sus scrofa)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Xenopus tropicalis)
Authored
Rothfels, K  (2017-09-29)
Reviewed
Magnani, L  (2018-02-23)
Created
Rothfels, K  (2017-07-12)
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