Reactome | The p75NTR:NgR:MDGI binds RHOA-GDI

The p75NTR:NgR:MDGI binds RHOA-GDI

Stable Identifier

R-HSA-9012761

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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In the presence of a myelin component (GMDI), such as MAG, NOGO or OMG, bound to a complex of the NOGO receptor (RTN4R, also known as NgR) and NGFR (p75NTR), binding of NGFR to ARHGDIA, a RHO-GDI, associated with RHOA:GDP, is strengthened (Yamashita and Tohyama 2003). The presence of LINGO1 in the complex of NGFR, RTN4R and MAG, NOGO or OMG is needed for NGFR-dependent activation of RHOA (Mi et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14966521	LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex Thill, G, Shao, Z, Crowell, T, Allaire, N, Cate, RL, Lee, X, Pepinsky, RB, Relton, J, Sands, B, Mi, S, Ji, B, Levesque, M, Perrin, S, McCoy, JM	Nat Neurosci	2004
12692556	The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI Yamashita, T, Tohyama, M	Nat Neurosci	2003