Ubiquitination of DLL/JAG ligands upon binding to NOTCH3

Stable Identifier
R-HSA-9013069
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Ubiquitination of DLL/JAG ligands upon binding to NOTCH3
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Based on an analogy with NOTCH1 and NOTCH2, and on studies of Drosophila Notch, NOTCH ligands DLL1, DLL4, JAG1 and JAG2 are assumed to undergo ubiquitination and endocytosis after binding to NOTCH3 in trans. Ubiquitination of DLL/JAG ligands in mammals is performed by orthologues of Drosophila Mindbomb, MIB1, possibly MIB2, and possibly orthologues of Drosophila Neuralized, NEURL and NEURL1B.

Participants
Input
Output
Entity On Other Cell
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as an event of
Event Information
Go Biological Process
Notch signaling pathway (0007219)
Catalyst Activity

ubiquitin-protein transferase activity of MIB/NEURL [cytosol]

Physical Entity
MIB/NEURL [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Inferred From
DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1) (Drosophila melanogaster)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-07-22)
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