RHOC GTPase cycle

Stable Identifier
Homo sapiens
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This pathway catalogues RHOC guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOC effectors. RHOC belongs to the RHOA subfamily of RHO GTPases and shares 85% sequence identity with RHOA and RHOB (Wheeler and Ridley 2004). Like RHOA and RHOB, RHOC regulates the cytoskeleton and is involved in cell adhesion and migration (Guan et al. 2018). RHOC contributes to invasiveness and metastatic potential of cancer cells (Bravo-Cordero et al. 2014; Guan et al. 2018; Thomas et al. 2019).

Literature References
PubMed ID Title Journal Year
31340863 RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target

Pranatharthi, A, Thomas, P, Ross, C, Srivastava, S

J. Exp. Clin. Cancer Res. 2019
28664531 The role of RhoC in malignant tumor invasion, metastasis and targeted therapy

Chen, S, Zhao, Y, Guan, X

Histol. Histopathol. 2018
24642482 Spatial regulation of tumor cell protrusions by RhoC

Condeelis, JS, Bravo-Cordero, JJ, Hodgson, L

Cell Adh Migr 2014
15501444 Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility

Ridley, AJ, Wheeler, AP

Exp. Cell Res. 2004
Orthologous Events
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