Reactome | RHOC GTPase cycle

RHOC GTPase cycle

Stable Identifier

R-HSA-9013106

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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This pathway catalogues RHOC guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOC effectors. RHOC belongs to the RHOA subfamily of RHO GTPases and shares 85% sequence identity with RHOA and RHOB (Wheeler and Ridley 2004). Like RHOA and RHOB, RHOC regulates the cytoskeleton and is involved in cell adhesion and migration (Guan et al. 2018). RHOC contributes to invasiveness and metastatic potential of cancer cells (Bravo-Cordero et al. 2014; Guan et al. 2018; Thomas et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
31340863	RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target Pranatharthi, A, Thomas, P, Ross, C, Srivastava, S	J. Exp. Clin. Cancer Res.	2019
28664531	The role of RhoC in malignant tumor invasion, metastasis and targeted therapy Chen, S, Zhao, Y, Guan, X	Histol. Histopathol.	2018
24642482	Spatial regulation of tumor cell protrusions by RhoC Condeelis, JS, Bravo-Cordero, JJ, Hodgson, L	Cell Adh Migr	2014
15501444	Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility Ridley, AJ, Wheeler, AP	Exp. Cell Res.	2004