Reactome | PSEN2(298-448) [plasma membrane]

PSEN2(298-448) [plasma membrane]

Stable Identifier

R-HSA-9013329

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PSEN2 C-terminal fragment, Presenilin-2 CTF subunit

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPH-ephrin mediated repulsion of cells (Homo sapiens)
        
        gamma-secretase cleaves EPHB2 (Homo sapiens)
        
        gamma-secretase complex [plasma membrane] (Homo sapiens)
        
        Presenilin [plasma membrane] (Homo sapiens)
        
        PSEN2 [plasma membrane] (Homo sapiens)
        
        PSEN2(298-448) [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49810 PSEN2

Gene Names

PSEN2, AD4, PS2, PSNL2, STM2

Chain

chain:1-297, chain:298-448

Reference Genes

BioGPS Gene:5664 PSEN2

COSMIC (genes):PSEN2 PSEN2

CTD Gene:5664 PSEN2

dbSNP Gene:5664 PSEN2

ENSEMBL:ENSG00000143801 PSEN2

ENSEMBL_homo_sapiens_GENE:ENSG00000143801.18 PSEN2

HGNC:9509 PSEN2

KEGG Gene (Homo sapiens):5664 PSEN2

Monarch:5664 PSEN2

NCBI Gene:5664 PSEN2

OMIM:600759 PSEN2

UCSC:P49810 PSEN2

Reference Transcript

Other Identifiers

11723672_a_at

11723673_a_at

11723674_x_at

11745866_a_at

11745867_x_at

11751163_a_at

16678169

204261_PM_s_at

204261_s_at

204262_PM_s_at

204262_s_at

211373_PM_s_at

211373_s_at

2383322

2383323

2383324

2383326

2383327

2383328

2383329

2383330

2383332

2383333

2383334

2383335

2383336

2383338

2383339

2383341

2383342

2383343

2383344

2383345

2383346

2383347

2383357

2383358

2383361

2383363

2383364

2383370

2383372

41349_at

5664

7910146

A_14_P136184

A_23_P103398

A_23_P96985

A_24_P62521

A_33_P3372924

GE57781

GO:0000139

GO:0000776

GO:0001666

GO:0003824

GO:0004175

GO:0004190

GO:0005515

GO:0005634

GO:0005635

GO:0005637

GO:0005694

GO:0005739

GO:0005743

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005813

GO:0005815

GO:0005856

GO:0005886

GO:0005929

GO:0005938

GO:0006508

GO:0006509

GO:0006816

GO:0007219

GO:0007220

GO:0008021

GO:0008233

GO:0009986

GO:0012501

GO:0016020

GO:0016324

GO:0016485

GO:0016787

GO:0023052

GO:0030018

GO:0030426

GO:0031410

GO:0031594

GO:0032991

GO:0034205

GO:0035253

GO:0035556

GO:0042500

GO:0042734

GO:0042987

GO:0043025

GO:0043066

GO:0043085

GO:0043198

GO:0043226

GO:0045121

GO:0048471

GO:0050435

GO:0051604

GO:0055085

GO:0070765

GO:0097060

GO:0110097

GO:0140096

GO:1990456

HMNXSV003034925

HMNXSV003038473

Hs.25363.0.A1_3p_s_at

ILMN_1675519

ILMN_1714417

ILMN_2404512

L43964_at

PH_hs_0002233

TC01001865.hg

g1079575_3p_s_at

Participates

as a component of

PSEN2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

PSEN2(1-297) [plasma membrane]

Inferred To

Homologues of PSEN2(298-448) [plasma membrane] (Sus scrofa)

Psen2(298-448) [plasma membrane] (Mus musculus)

Psen2(298-448) [plasma membrane] (Rattus norvegicus)

psen2 [plasma membrane] (Danio rerio)

psen2 [plasma membrane] (Xenopus tropicalis)

PSEN2 [plasma membrane] (Bos taurus)

PSEN2 [plasma membrane] (Canis familiaris)

PSEN2 [plasma membrane] (Gallus gallus)

PSEN2 [plasma membrane] (Sus scrofa)

Psn [plasma membrane] (Drosophila melanogaster)

sel-12 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000438.2, NP_036618.2, XP_016857324.1, XP_016857325.1, XP_005273256.1

Guide to Pharmacology - Targets

2403

OpenTargets

ENSG00000143801

ZINC - Substances

PSN2_HUMAN

ZINC target

P49810

PRO

P49810

PDB

7Y5Z, 7Y5X

HPA

ENSG00000143801-PSEN2

GeneCards

P49810

Ensembl

ENSP00000403737, ENSG00000143801, ENST00000524196, ENSP00000429036, ENST00000626989, ENST00000678233, ENSP00000486498, ENST00000422240, ENSP00000355746, ENSP00000355747, ENSP00000504728, ENSP00000504727, ENST00000679098, ENSP00000503116, ENST00000366782, ENST00000679088, ENST00000366783, ENST00000677414, ENSP00000504303

Pharos - Targets

P49810

ZINC - Predictions - Purchasable

PSN2_HUMAN

Orphanet

15161

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.675	4
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.593	3
UniProt:P54819 AK2	1	AK2 [mitochondrial intermembrane space] (R-HSA-57822)	0.556	3
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.556	3
UniProt:Q96NC0 ZMAT2	1	ZMAT2 [nucleoplasm] (R-HSA-9770248)	0.556	3
UniProt:P30626 SRI	1	SRI [sarcoplasmic reticulum membrane] (R-HSA-5490313)	0.544	2
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.543	3
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.524	4
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.508	2
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.508	2
UniProt:Q53EL6 PDCD4	1	PDCD4 [cytosol] (R-HSA-5432887)	0.482	3