Reactome | RAC2 GTPase cycle

RAC2 GTPase cycle

Stable Identifier

R-HSA-9013404

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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This pathway catalogues RAC2 guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RAC2 effectors. RAC2 is exclusively expressed in hematopoietic cells (Troeger and Williams 2013). RAC2 is a component of the phagocytic oxidase complex in neutrophils (Troeger and Williams 2013). RAC2 is required for adhesion and mobilization of hematopoietic stem cells and progenitor cells (Troeger and Williams 2013). RAC2 is also needed for adhesion, migration and degranulation of mast cells (Troeger and Williams 2013). Mutations in RAC2 have been found in a small number of patients with primary immunodeficiencies (Gu and Williams 2002; Troeger and Williams 2013; Lougaris et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
23850828	Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders Troeger, A, Williams, DA	Exp. Cell Res.	2013
32542921	RAC2 and primary human immune deficiencies Benvenuto, A, Baronio, M, Plebani, A, Lougaris, V, Gazzurelli, L	J. Leukoc. Biol.	2020
12468931	RAC2 GTPase deficiency and myeloid cell dysfunction in human and mouse Gu, Y, Williams, DA	J. Pediatr. Hematol. Oncol.	2002