activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]

Stable Identifier
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
16115877 Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

Fitzgerald, KA, Cusson-Hermance, N, Khurana, S, Kelliher, MA, Lee, TH

J Biol Chem 2005
15814722 Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

Offermann, MK, Kaiser, WJ

J Immunol 2005
22421964 dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

Pierrot, A, Salaun, B, Lalaoui, N, Jacquemin, G, Micheau, O, Renno, T, Bonnin, M, Vanbervliet, B, Virard, F, Estornes, Y, Lebecque, S, Pachéco, Y, Toscano, F, Mercier-Gouy, P

Cell Death Differ. 2012
21737330 cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

Langlais, C, Geserick, P, Kellert, B, Häcker, G, Cain, K, Feoktistova, M, Hupe, M, MacFarlane, M, Leverkus, M, Dimitrova, DP

Mol. Cell 2011
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