RHOG binds effectors at the plasma membrane

Stable Identifier
R-HSA-9014449
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated GTP bound RHOG binds to the following effectors at the plasma membrane:
DOCK1 (Katoh et al. 2006, Bagci et al. 2020)
DOCK2 (Damoulakis et al. 2014)
DOCK3 (Namekata et al. 2012)
DOCK4 (Hiramoto‑Yamaki et al. 2010, Hiramoto et al. 2006, Bagci et al. 2020 )
IQGAP2 (Wennerberg et al. 2002)
MAP3K11 (Wennerberg et al. 2002)
PLEKHG3 (Bagci et al. 2020)
PLD1 (Wennerberg et al. 2002)

The following candidate effectors that localize to the plasma membrane or cytosol have been found to bind to active RHOG in the high throughput screen by Bagci et al. 2020:
ARFGAP3 (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CDC42EP1 (Bagci et al. 2020)
CYFIP1 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
DOCK5 (Bagci et al. 2020)
DSG2 (Bagci et al. 2020)
ELMO2 (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
ERBIN (Bagci et al. 2020)
HSPE1 (Bagci et al. 2020)
ITGB1 (Bagci et al. 2020)
KIAA0355 (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MPP7 (Bagci et al. 2020)
NDUFA5 (Bagci et al. 2020)
NDUFS3 (Bagci et al. 2020)
PAK2 (Bagci et al. 2020)
PAK4 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SHMT2 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)

Activated RHOG does not act on or does not bind to the following putative effectors in the high throughput screen by Bagci et al. 2020:
ABI1 (Bagci et al. 2020)
ABI2 (Bagci et al. 2020)
ABL2 (Bagci et al. 2020)
AMIGO2 (Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARMCX3 (Bagci et al. 2020)
BAIAP2 (Wennerberg et al. 2002, Bagci et al. 2020)
BAIAP2L1 (Bagci et al. 2020)
BRK1 (Bagci et al. 2020)
CDC42EP4 (Bagci et al. 2020)
FERMT2 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
IL32 (Bagci et al. 2020)
JAG1 (Bagci et al. 2020)
NCKAP1 (Bagci et al. 2020)
NHS (Bagci et al. 2020)
PAK1 (Wennerberg et al. 2002)
PAK5 (Wennerberg et al. 2002)
PAK6 (Wennerberg et al. 2002)
PARD6A (Wennerberg et al. 2002)
PLEKHG4 (Bagci et al. 2020)
RAPGEF1 (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLITRK3 (Bagci et al. 2020)
SLITRK5 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SWAP70 (Bagci et al. 2020)
TAOK3 (Bagci et al. 2020)
WAS (WASP) (Wennerberg et al. 2002)
WASF1 (Bagci et al. 2020)
WASF2 (Bagci et al. 2020)

Activated RHOG interacts with the WAVE complex component CYFIP1 (Bagci et al. 2020), but not with the WAVE complex components WASF1 and WASF2 (Bagci et al. 2020). The WAVE complex is not annotated as a RHOG effector.
Literature References
PubMed ID Title Journal Year
22734669 Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG

Harada, T, Watanabe, H, Namekata, K, Kimura, A, Guo, X, Harada, C, Kawamura, K, Kittaka, D

Genes Cells 2012
17027967 Dock4 is regulated by RhoG and promotes Rac-dependent cell migration

Hiramoto, K, Katoh, H, Negishi, M

Exp Cell Res 2006
12376551 RhoG signals in parallel with Rac1 and Cdc42

Burridge, K, Karnoub, AE, Ellerbroek, SM, Liu, RY, Wennerberg, K, Der, CJ

J. Biol. Chem. 2002
16339170 Activation of Rac1 by RhoG regulates cell migration

Katoh, H, Negishi, M, Hiramoto, K

J. Cell. Sci. 2006
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP

Nat. Cell Biol. 2020
24659802 P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils

Fukui, Y, Damoulakis, G, Welch, HC, Anderson, KE, Rossman, KL, Hawkins, PT, Gambardella, L, Lawson, CD, Stephens, LR, Der, CJ

J. Cell. Sci. 2014
20679435 Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism

Katoh, H, Ueda, S, Hiramoto-Yamaki, N, Takeuchi, S, Harada, K, Fujimoto, S, Negishi, M

J. Cell Biol. 2010
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!