Reactome | SDS dimers:PXLP convert L-Thr to 2OBUTA

SDS dimers:PXLP convert L-Thr to 2OBUTA

Stable Identifier

R-HSA-9014627

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

L-threonine => 2-oxobutanoate + NH4(+)

ReviewStatus

5/5

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Both SDS (L-serine dehydratase/L-threonine deaminase) and SDSL (Serine dehydratase-like), covalently conjugated with PXLP, form dimers that catalyze the reaction of L-threonine (L-Thr) to form 2-oxobutanoate (2OBUTA) and ammonium (NH4+). These reactions occur in the cytosol (Ogawa et al. 2006; Yamada et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
15689518	Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver Bartlam, M, Rao, Z, Pang, H, Liu, Y, Sun, L	Protein Sci.	2005
18342636	A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies Yamada, T, Ogawa, H, Kasuya, T, Takata, Y, Komoto, J, Takusagawa, F, Mori, H	Biochim. Biophys. Acta	2008