Translation of ROBO3.2 mRNA is negatively regulated by NMD

Stable Identifier
R-HSA-9014652
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Translation of ROBO3.2 mRNA is negatively regulated by NMD
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Based on studies in mice, translation of ROBO3.2 mRNA in commissural axons at the floor plate is negatively regulated by nonsense mediated decay (NMD). Deficiency of NMD components results in aberrant axonal trajectories after crossing the midline (Colak et al. 2013).
Literature References
PubMed ID Title Journal Year
23746841 Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay

Jaffrey, SR, Ji, SJ, Porse, BT, Colak, D

Cell 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
Active Unit
Exon Junction:UPF2:UPF3 Complex [cytosol]
Inferred From
Translation of Robo3.2 mRNA is negatively regulated by NMD (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-23)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-08-02)
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