FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3

Stable Identifier
R-HSA-9016751
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3
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Based on studies in mice, expression of FABP7 (BLBP) in radial glia is positively regulated by NOTCH1 and NOTCH3 during neuronal migration (Anthony et al. 2005, Keilani and Sugaya 2008). The promoter of the mouse Fabp7 gene contains an Rbpj binding site needed for Fabp7 expression (Anthony et al. 2005). Several sites related to the consensus RBPJ binding sequence exist in the human FABP7 gene promoter.
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as an event of
Event Information
Go Biological Process
positive regulation of transcription of Notch receptor target (0007221)
This event is regulated
Positively by
Regulator
NOTCH1,NOTCH3 coactivator complexes [nucleoplasm] (Homo sapiens)
Inferred From
Fabp7 gene expression is positively regulated by Notch1 and Notch3 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-08-15)
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