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CALM1 [plasma membrane]
Stable Identifier
R-HSA-9016884
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Calmodulin, CALM_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
AKT1 binds eNOS complex via HSP90 (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
AKT1 phosphorylates eNOS (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
AKT1 binds eNOS complex via HSP90 (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
AKT1 phosphorylates eNOS (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate IQGAPs (Homo sapiens)
IQGAPs bind CALM1 (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
IQGAPs bind F-actin, which is inhibited by calmodulin (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
CALM1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P0DP23 CALM1
Gene Names
CALM1, CALM, CAM, CAM1
Chain
initiator methionine:1, chain:2-149
Reference Genes
BioGPS Gene:801 CALM
BioGPS Gene:805 CALM
BioGPS Gene:808 CALM
COSMIC (genes):CALM1 CALM1
CTD Gene:801 CALM
CTD Gene:805 CALM
CTD Gene:808 Q9BRL5
dbSNP Gene:801 CALM
dbSNP Gene:805 CALM
dbSNP Gene:808 CALM
ENSEMBL:ENSG00000198668 CALM1
HGNC:1442 CALM1
KEGG:hsa:801 CALM
KEGG:hsa:805 CALM
KEGG:hsa:808 CALM
Monarch:801 CALM
Monarch:805 CALM
Monarch:808 CALM
NCBI Gene:801 CALM
NCBI Gene:805 CALM
NCBI Gene:808 CALM
OMIM:114180 CALM
UCSC:P0DP23 CALM1
Reference Transcript
RefSeq:NM_001329922.1 CALM
RefSeq:NM_006888.6 CALM
RefSeq:NM_001743.5 CALM
RefSeq:NM_005184.3 CALM
Other Identifiers
11724759_s_at
11724760_a_at
11724761_s_at
11749472_a_at
16787430
200653_PM_s_at
200653_s_at
200655_PM_s_at
200655_s_at
209563_PM_x_at
209563_x_at
211984_PM_at
211984_at
211985_PM_s_at
211985_s_at
213688_PM_at
213688_at
241619_PM_at
241619_at
244869_PM_at
244869_at
3548350
3548351
3548352
3548353
3548354
3548355
3548356
3548357
3548358
3548359
3548360
3548361
3548362
3548363
3548364
3548365
3548366
3548367
3548368
3548369
3548370
3548371
3548372
3548373
3548374
3548375
3548376
3548377
3983844
41143_at
41144_g_at
41288_at
51680_at
67743_at
7976200
801
955_at
A_14_P129512
A_23_P163178
A_24_P313186
GE569065
GE744532
GO:0000086
GO:0000922
GO:0002027
GO:0005246
GO:0005509
GO:0005513
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005876
GO:0005886
GO:0005929
GO:0007186
GO:0007259
GO:0008076
GO:0008092
GO:0010856
GO:0010880
GO:0010881
GO:0016020
GO:0016192
GO:0016240
GO:0016301
GO:0019855
GO:0019901
GO:0021762
GO:0030017
GO:0030672
GO:0031432
GO:0031514
GO:0031982
GO:0032465
GO:0032991
GO:0034704
GO:0035458
GO:0042995
GO:0043209
GO:0043226
GO:0043539
GO:0044305
GO:0044325
GO:0046427
GO:0046872
GO:0048306
GO:0048856
GO:0050848
GO:0051592
GO:0055117
GO:0060291
GO:0060314
GO:0060315
GO:0071346
GO:0072542
GO:0097225
GO:0097720
GO:0098772
GO:0098901
GO:0099523
GO:0140056
GO:0140238
GO:0141110
GO:1901842
GO:1901844
GO:1902494
GO:1905913
GO:1990456
HMNXSV003017168
Hs.252730.0.S1_3p_at
Hs.270922.0.A1_3p_at
Hs.279009.6.A1_3p_at
ILMN_1778242
PH_hs_0023451
TC14000554.hg
g179809_3p_s_at
g5901911_3p_a_at
Participates
as a component of
CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
Other forms of this molecule
CALM1 [cytosol]
CALM1 [nucleoplasm]
Me3K116-CALM1 [cytosol]
CALM1 [extracellular region]
Inferred To
pat-10 [plasma membrane]
(Caenorhabditis elegans)
cal-4 [plasma membrane]
(Caenorhabditis elegans)
cal-1 [plasma membrane]
(Caenorhabditis elegans)
CALM1 [plasma membrane]
(Bos taurus)
CALM1 [plasma membrane]
(Caenorhabditis elegans)
CALM1 [plasma membrane]
(Canis familiaris)
TpnC47D [plasma membrane]
(Drosophila melanogaster)
tnc-2 [plasma membrane]
(Caenorhabditis elegans)
Calm3 [plasma membrane]
(Rattus norvegicus)
TpnC4 [plasma membrane]
(Drosophila melanogaster)
cal-3 [plasma membrane]
(Caenorhabditis elegans)
CG10022 [plasma membrane]
(Drosophila melanogaster)
cal-2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of CALM1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of CALM1 [plasma membrane]
(Drosophila melanogaster)
TpnC41C [plasma membrane]
(Drosophila melanogaster)
TpnC73F [plasma membrane]
(Drosophila melanogaster)
Ghost homologue of CALM1 [plasma membrane]
(Dictyostelium discoideum)
Ghost homologue of CALM1 [plasma membrane]
(Saccharomyces cerevisiae)
Ghost homologue of CALM1 [plasma membrane]
(Schizosaccharomyces pombe)
Ghost homologue of CALM1 [plasma membrane]
(Sus scrofa)
azot [plasma membrane]
(Drosophila melanogaster)
Calm1 [plasma membrane]
(Mus musculus)
TpnC25D [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001734.1
,
NP_005175.2
,
NP_008819.1
,
NP_001316851.1
OpenTargets
ENSG00000198668
ENSEMBL
ENSG00000198668
,
ENSP00000349467
,
ENST00000356978
HPA
ENSG00000198668-CALM1
GeneCards
CALM1
PRO
P0DP23
Pharos - Targets
P0DP23
GlyGen
P0DP23
PDB
5JTH
,
6CNN
,
7UA3
,
2M0J
,
8GM4
,
6HCS
,
4BYF
,
6FEG
,
4BW7
,
1XFX
,
8DGK
,
6V00
,
5TP6
,
7XN5
,
6HR1
,
8J03
,
6DAE
,
5GGM
,
6U39
,
6E2F
,
7VUU
,
5WBX
,
1S26
,
5DBR
,
8IJK
,
8EOW
,
5V02
,
2F3Y
,
7WR4
,
8J01
,
8XYB
,
6K4R
,
8XJI
,
4UMO
,
1LVC
,
6CNM
,
7BF2
,
2M0K
,
1L7Z
,
8J07
,
6X33
,
7VVD
,
7T2Q
,
4BW8
,
6JII
,
7BF1
,
2LGF
,
1XFY
,
7XN6
,
6V01
,
8J02
,
6B8Q
,
2KNE
,
8OE0
,
6GDK
,
8AHS
,
7VUT
,
2Y4V
,
2N77
,
6M2W
,
8SIM
,
1K90
,
1YRU
,
6Y95
,
1UP5
,
6K4L
,
7L8V
,
5COC
,
8J00
,
8Y40
,
5DOW
,
6PBY
,
2KUH
,
5K8Q
,
3BYA
,
6YNU
,
4JPZ
,
6O5G
,
2L7L
,
3EWV
,
6XXX
,
6PAW
,
2L53
,
7AUG
,
6B8P
,
3UCY
,
2MG5
,
6JI8
,
5WC5
,
2LQP
,
1PK0
,
7WJI
,
6EEB
,
7ZRP
,
8JFK
,
7PSZ
,
6ZBI
,
7U9T
,
1CLL
,
3O77
,
6YNS
,
8DUJ
,
7UA4
,
5DSU
,
6UZZ
,
8UXL
,
2LL6
,
8XKH
,
6DAH
,
5J03
,
3DVK
,
6X32
,
6DAD
,
1SK6
,
4UPU
,
1XFW
,
8X43
,
3DVM
,
6BUT
,
4DJC
,
8OE4
,
1J7O
,
1XFV
,
2R28
,
2LQC
,
6GDL
,
6B8N
,
7VUR
,
8XLF
,
2N6A
,
8EP1
,
6Y4P
,
8W4U
,
6U3A
,
6JIU
,
7VMB
,
1CTR
,
7WR5
,
1SW8
,
3O78
,
2KUG
,
8XYA
,
5I0I
,
1NKF
,
6XY3
,
6OS4
,
3EWT
,
7PU9
,
7VVH
,
2LV6
,
4L79
,
6E2G
,
6C1G
,
9K8X
,
5OEO
,
2V02
,
4JQ0
,
4OVN
,
6B8M
,
9CUK
,
4V0C
,
2K0E
,
8EP0
,
8PB1
,
5V03
,
8FNY
,
6U3B
,
7WZS
,
3J41
,
8FO6
,
8DVE
,
5JQA
,
7TCP
,
2WEL
,
4GOW
,
8UXM
,
2LL7
,
6C1D
,
4LZX
,
3UCW
,
5TP5
,
7XN4
,
1J7P
,
3G43
,
4Q57
,
1XFU
,
6DAF
,
2VAY
,
6U3D
,
7VUS
,
6B8L
,
4M1L
,
4Q5U
,
7ZRQ
,
7VUO
,
2K0J
,
7WR3
,
7TCI
,
5K7L
,
1YR5
,
1ZUZ
,
2W73
,
3HR4
,
2JZI
,
6CNO
,
7SX3
,
9JQI
,
7SX4
,
2BE6
,
6N5W
,
6X36
,
2N27
,
6FEH
,
8B6Q
,
6JRS
,
1XFZ
,
7TZC
,
6JV2
,
8DGH
,
8J05
,
8XLH
,
2V01
,
1IWQ
,
6XYR
,
1K93
,
2M55
,
8SIK
,
3OXQ
,
6MUD
,
6Y94
,
2X0G
,
5J8H
,
1ZOT
,
6K4K
,
1Y6W
,
7KL5
,
2HF5
,
6PBX
,
8GM5
,
9E17
,
9CUI
,
7SHQ
,
2K61
,
6X35
,
8XO1
,
6TV7
,
1WRZ
,
2N8J
,
6C1H
,
3UCT
,
4DCK
,
9K8W
,
8J04
,
3DVJ
,
8SIN
,
2I08
,
6M7H
,
3SUI
,
1CDL
,
6MUE
,
1YRT
,
3DVE
,
6JIY
,
8BFG
,
2K0F
,
6YA9
,
2F3Z
,
8ODZ
,
3EVV
,
5V7X
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75874 IDH1
10
IDH1 [cytosol]
(R-HSA-389549)
IDH1 [peroxisomal matrix]
(R-HSA-389546)
IDH1 [tertiary granule lumen]
(R-HSA-6800163)
IDH1 [extracellular region]
(R-HSA-6806433)
IDH1 [secretory granule lumen]
(R-HSA-6800980)
IDH1 [ficolin-1-rich granule lumen]
(R-HSA-6800977)
IDH1 R132C mutant [cytosol]
(R-HSA-880031)
IDH1 R132S mutant [cytosol]
(R-HSA-880048)
IDH1 R132L mutant [cytosol]
(R-HSA-880000)
IDH1 R132H mutant [cytosol]
(R-HSA-880015)
0.65
7
UniProt:Q5JU85 IQEC2
0.564
2
UniProt:P15735 PHKG2
1
PHKG2 [cytosol]
(R-HSA-71533)
0.527
2
UniProt:Q5T4S7 UBR4
5
UBR4 [cytosol]
(R-HSA-976045)
UBR4 [ficolin-1-rich granule membrane]
(R-HSA-6801503)
UBR4 [plasma membrane]
(R-HSA-6801583)
UBR4 [specific granule membrane]
(R-HSA-6801492)
UBR4 [tertiary granule membrane]
(R-HSA-6801489)
0.527
2
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