PPARG gene expression is inhibited by MECP2

Stable Identifier
R-HSA-9017441
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in mouse hepatocytes (Mann et al. 2011) and rat lung cells (Joss-Moore et al. 2011), transcription of the PPARG gene is inhibited by binding of MECP2 to PPARG promoter. Binding of MECP2 to the PPAR gene correlates with the appearance of repressive methylation marks on histones associated with the PPARG promoter (Mann et al. 2010).
Participants
Participates
This event is regulated
Inferred From
Authored
Reviewed
Created
Cite Us!