Reactome | RHOJ GAPs stimulate RHOJ GTPase activity

RHOJ GAPs stimulate RHOJ GTPase activity

Stable Identifier

R-HSA-9017488

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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RHOJ GAPs stimulate RHOJ GTPase activity

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The following GTPase activating proteins (GAPs) were shown to bind RHOJ and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOJ:GTP complex into the inactive RHOJ:GDP complex (the high throughput study by Bagci et al. 2020 examined binding of GAPs to constitutively active RHOJ mutant without testing for RHOJ-directed GAP activity, and is cited as supporting evidence):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
ARHGAP35 (Amin et al. 2016; supported by Bagci et al. 2020)

The following GAPs were shown to bind RHOJ and stimulate its GTPase activity in some but not all studies or were shown by Bagci et al. 2020 to bind to constitutively active RHOJ mutant without testing for RHOJ-directed GAP activity and are annotated as candidate RHOJ GAPs:
ARHGAP5 (Bagci et al. 2020)
ARHGAP21 (Bagci et al. 2020)
ARHGAP32 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
OCRL (Bagci et al. 2020: binding to active RHOJ)
OPHN1 (Amin et al. 2016: RHOJ directed GAP activity; Bagci et al. 2020: no binding to active RHOJ)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
SYDE1 (Bagci et al. 2020)

The following GAPs do not act on RHOJ or were shown by Bagci et al. 2020 to no bind to constitutively active RHOJ mutant and are thus unlikely to be RHOJ GAPs:
ABR (Amin et al. 2016; Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARAP3 (Bagci et al. 2020)
ARHGAP12 (Bagci et al. 2020)
ARHGAP17 (Amin et al. 2016; Bagci et al. 2020)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
ARHGAP42 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
DLC1 (Amin et al. 2016)
MYO9A (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
RACGAP1 (Amin et al. 2016; Bagci et al. 2020)
SRGAP2 (Bagci et al. 2020)
STARD13 (Amin et al. 2016)
STARD8 (Amin et al. 2016)

Literature References

PubMed ID	Title	Journal	Year
27481945	Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS Ahmadian, MR, Somlyo, AV, Amin, E, Koessmeier, KT, Jaiswal, M, Dvorsky, R, Reis, K, Derewenda, U, Nouri, K, Aspenström, P	J. Biol. Chem.	2016
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP	Nat. Cell Biol.	2020