FOXA1 and GATA3 bind TFF genes

Stable Identifier
R-HSA-9018494
Type
Reaction [transition]
Species
Homo sapiens
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Trefoil factor family (TFF) 1 and 3 are secreted in mucous epithelia and the nervous system and have been implicated in oncogenesis and metastasis (reviewed in Busch and Dünker, 2015). TFF1 and 3 are estrogen-responsive genes with ESR1-bound promoters/enhancers that are primed for ligand-dependent expression by the binding of 'pioneer' transcription factors, such as FOXA1 and GATA3 (Berry et al, 1989; Shang et al, 2000; Carroll et al, 2005; Laganière et al, 2005; Eeckhoute et al, 2006; Hurtado et al, 2011; Kong et al, 2011; Theodorou et al, 2013; reviewed in Zaret and Carroll, 2011; Augello et al, 2011; Fiorito et al, 2013; Wilson and Giguere, 2008). FOXA factors have a winged helix structure that is thought to bind to closed chromatin structures in a manner analogous to linker histones, displacing linker histones and rendering the DNA more accessible to other transcription factors (reviewed in Zaret and Carroll, 2011). FOXA binding sites tend to be enriched at enhancer elements, characterized by H3K4 mono- and dimethylation and H3K27 acetylation, active histone markers (Heintzman et al, 2009; Creyghton et al, 2010; Theodorou et al, 2013).

Literature References
PubMed ID Title Journal Year
21878914 Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state

Kong, SL, Li, G, Liu, ET, Loh, SL, Sung, WK

Mol. Syst. Biol. 2011
16980581 A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer

Brown, M, Geistlinger, TR, Torres-Arzayus, MI, Eeckhoute, J, Carroll, JS

Genes Dev. 2006
11452016 Estrogen receptor interaction with estrogen response elements

Klinge, CM

Nucleic Acids Res. 2001
21934649 FOXA1: master of steroid receptor function in cancer

Augello, MA, Hickey, TE, Knudsen, KE

EMBO J. 2011
23192763 Cooperating transcription factors mediate the function of estrogen receptor

Hurtado, A, Fiorito, E, Katika, MR

Chromosoma 2013
21151129 FOXA1 is a key determinant of estrogen receptor function and endocrine response

Ross-Innes, CS, Hurtado, A, Carroll, JS, Holmes, KA, Schmidt, D

Nat. Genet. 2011
16009131 Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1

Szary, AJ, Shao, W, Li, W, Geistlinger, TR, Liu, XS, Hestermann, EV, Meyer, CA, Brodsky, AS, Silver, PA, Fox, EA, Brown, M, Eeckhoute, J, Carroll, JS

Cell 2005
11136970 Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

Hu, X, Brown, M, DiRenzo, J, Shang, Y, Lazar, MA

Cell 2000
2919170 Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence

Chambon, P, Nunez, AM, Berry, M

Proc. Natl. Acad. Sci. U.S.A. 1989
16087863 From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response

Bataille, AR, Giguère, V, Robert, F, Lefebvre, C, Laganière, J, Deblois, G

Proc. Natl. Acad. Sci. U.S.A. 2005
19295514 Histone modifications at human enhancers reflect global cell-type-specific gene expression

Thomson, JA, Ye, Z, Hawkins, RD, Stuart, RK, Crawford, GE, Lee, LK, Stark, A, Liu, H, Kellis, M, Lobanenkov, VV, Ren, B, Kheradpour, P, Stewart, R, Hon, GC, Ching, KA, Harp, LF, Green, RD, Antosiewicz-Bourget, JE, Zhang, X, Heintzman, ND, Ching, CW

Nature 2009
22056668 Pioneer transcription factors: establishing competence for gene expression

Zaret, KS, Carroll, JS

Genes Dev. 2011
23172872 GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility

Stark, R, Menon, S, Carroll, JS, Theodorou, V

Genome Res. 2013
21106759 Histone H3K27ac separates active from poised enhancers and predicts developmental state

Boyer, LA, Sharp, PA, Cheng, AW, Carey, BW, Young, RA, Hanna, J, Frampton, GM, Jaenisch, R, Welstead, GG, Lodato, MA, Steine, EJ, Kooistra, T, Creyghton, MP

Proc. Natl. Acad. Sci. U.S.A. 2010
26479350 Trefoil factor family peptides--friends or foes?

Busch, M, Dünker, N

Biomol Concepts 2015
18533032 Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway

Giguère, V, Wilson, BJ

Mol. Cancer 2008
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