Estrogen-responsive TFF3 gene expression

Stable Identifier
R-HSA-9018497
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Estrogen-responsive TFF3 gene expression
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Estrogen-dependent TFF3 expression is promoted by the formation of FOXA1- and GATA3-dependent chromatin loops. Interaction of ligand-bound ESR1 with the enhancer promotes recruitment of EP300 and other chromatin modifying enzymes, and stimulates the deposition of active chromatin marks like H3K4 methylation and H3K27 acteylation (Laganière et al, 2005; Theodorou et al, 2013; reviewed in Zaret and Carroll, 2011)
Literature References
PubMed ID Title Journal Year
22056668 Pioneer transcription factors: establishing competence for gene expression

Zaret, KS, Carroll, JS

Genes Dev. 2011
23172872 GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility

Stark, R, Menon, S, Carroll, JS, Theodorou, V

Genome Res. 2013
23192763 Cooperating transcription factors mediate the function of estrogen receptor

Hurtado, A, Fiorito, E, Katika, MR

Chromosoma 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TFF3 gene:FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm] (Homo sapiens)
Active Unit
FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm]
Authored
Rothfels, K  (2017-09-29)
Reviewed
Magnani, L  (2018-02-23)
Created
Rothfels, K  (2017-09-01)
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