DLGAP5 gene transcription is stimulated by NOTCH3

Stable Identifier
R-HSA-9018538
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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DLGAP5 gene transcription is stimulated by NOTCH3
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Binding of the NOTCH3 coactivator complex to RBPJ response elements in the promoter of the DLGAP5 gene stimulates DLGAP5 transcription. DLGAP5 is involved in G2/M transition and is overexpressed in ovarian cancer cells. NOTCH3 gene is frequently amplified in ovarian cancer (Chen et al. 2012).
Literature References
PubMed ID Title Journal Year
22396495 Defining NOTCH3 target genes in ovarian cancer

Chen, X, Gao, M, Xuan, J, Chen, L, Wang, TL, Stoeck, A, Shih, IeM, Thiaville, MM

Cancer Res. 2012
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
positive regulation of transcription of Notch receptor target (0007221)
This event is regulated
Positively by
Regulator
NOTCH3 coactivator complex:DLGAP5 gene [nucleoplasm] (Homo sapiens)
Active Unit
NOTCH3 coactivator complex [nucleoplasm]
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-09-01)
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