RHOQ GAPs stimulate RHOQ GTPase activity

Stable Identifier
R-HSA-9018745
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The following GTPase activating proteins (GAPs) were shown to bind RHOQ and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOQ:GTP complex to the inactive RHOQ:GDP complex (the study by Bagci et al. 2020 examined binding of GAPs to constitutively active RHOQ mutant, without assessing RHOQ-directed GAP activity and is cited as supporting evidence):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
DLC1 (Amin et al. 2016)

The following GAPs were shown to bind RHOQ and stimulate its GTPase activity in some but not all studies or were only shown by Bagci et al. 2020 to bind active RHOQ without testing for RHOQ-directed GAP activity and are annotated as candidate RHOQ GAPs:
ARHGAP5 (Bagci et al. 2020)
ARHGAP17 (Amin et al. 2016: RHOQ directed GAP activity; Bagci et al. 2020: no binding to active RHOQ)
ARHGAP21 (Bagci et al. 2020)
ARHGAP32 (Bagci et al. 2020)
ARHGAP35 (Amin et al. 2016: RHOQ directed GAP activity; Bagci et al. 2020: no binding to active RHOQ)
DEPDC1B (Bagci et al. 2020)
OPHN1 (Amin et al. 2016: RHOQ directed GAP activity; Bagci et al. 2020: no binding to active RHOQ)
SRGAP2 (Bagci et al. 2020)
SYDE1 (Bagci et al. 2020)

The following GAPs do not act on RHOQ or were shown by Bagci et al. 2020 to not bind to active RHOQ, without testing for their RHOQ-directed GAP activity:
ABR (Amin et al. 2016; Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARAP3 (Bagci et al. 2020)
ARHGAP12 (Bagci et al. 2020)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
ARHGAP42 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
MYO9A (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
OCRL (Bagci et al. 2020)
RACGAP1 (Amin et al. 2016; Bagci et al. 2020)
STARD13 (Amin et al. 2016)
STARD8 (Amin et al. 2016)
Literature References
PubMed ID Title Journal Year
27481945 Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS

Ahmadian, MR, Somlyo, AV, Amin, E, Koessmeier, KT, Jaiswal, M, Dvorsky, R, Reis, K, Derewenda, U, Nouri, K, Aspenström, P

J. Biol. Chem. 2016
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP

Nat. Cell Biol. 2020
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Catalyst Activity

GTPase activator activity of RHOQ GAPs [cytosol]

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