RHOU auto-activates

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
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RHOU is an atypical RHO GTPase with a high intrinsic guanine nucleotide exchange activity. Guanine nucleotide exchange factors (GEFs) are not needed for RHOU activation (Shutes et al. 2004, Saras et al. 2004). While some GTPase activator proteins (GAPs) have been reported to interact with RHOU (Bagci et al. 2020), they have not been shown to act on RHOU. Instead, GAPs may serve as RHOU effectors that enable its cross talk with other RHO GTPases (reviewed in Hodge and Ridley 2020). RHOU was shown to possess GTPase activity (Shutes et al. 2004), but the functional importance of GTP hydrolysis in the context of high intrinsic GEF activity and no known GAPs has not been elucidated.

Literature References
PubMed ID Title Journal Year
15350535 Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects

Wollberg, P, Saras, J, Aspenström, P

Exp. Cell Res. 2004
15556869 Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase

Der, CJ, Shutes, A, Cox, AD, Berzat, AC

Curr. Biol. 2004
Catalyst Activity

guanyl-nucleotide exchange factor activity of RHOU:GDP [plasma membrane]

Orthologous Events
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