Reactome | TUBB [cytosol]

TUBB [cytosol]

Stable Identifier

R-HSA-9020816

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tubulin beta-5 chain, TUBB5

Locations in the PathwayBrowser for interactor UniProt:Q00005 2ABB

Expand all

External Reference Information

External Reference

UniProt:P07437 TUBB

Gene Names

TUBB, TUBB5, OK/SW-cl.56

Chain

chain:1-444

Reference Genes

BioGPS Gene:203068 TUBB

COSMIC (genes):TUBB TUBB

CTD Gene:203068 TUBB

dbSNP Gene:203068 TUBB

ENSEMBL:ENSG00000183311 TUBB

ENSEMBL:ENSG00000196230 TUBB

ENSEMBL:ENSG00000224156 TUBB

ENSEMBL:ENSG00000227739 TUBB

ENSEMBL:ENSG00000229684 TUBB

ENSEMBL:ENSG00000232421 TUBB

ENSEMBL:ENSG00000232575 TUBB

ENSEMBL:ENSG00000235067 TUBB

ENSEMBL_homo_sapiens_GENE:ENSG00000183311.16 TUBB

ENSEMBL_homo_sapiens_GENE:ENSG00000196230.14 TUBB

ENSEMBL_homo_sapiens_GENE:ENSG00000224156.10 TUBB

ENSEMBL_homo_sapiens_GENE:ENSG00000227739.10 TUBB

ENSEMBL_homo_sapiens_GENE:ENSG00000229684.10 TUBB

ENSEMBL_homo_sapiens_GENE:ENSG00000232421.10 TUBB

ENSEMBL_homo_sapiens_GENE:ENSG00000232575.10 TUBB

ENSEMBL_homo_sapiens_GENE:ENSG00000235067.10 TUBB

HGNC:20778 TUBB

KEGG Gene (Homo sapiens):203068 TUBB

Monarch:203068 TUBB

NCBI Gene:203068 TUBB

OMIM:191130 TUBB

Reference Transcript

Other Identifiers

11724732_s_at

11748481_x_at

11752877_x_at

11752922_x_at

11753356_x_at

11753891_x_at

151_s_at

17006378

17026211

17027559

17030404

17033109

17035229

17037888

17040602

203068

209026_PM_x_at

209026_x_at

211714_PM_x_at

211714_x_at

212320_PM_at

212320_at

2336645

2901914

2901915

2901919

2901921

2901922

2901923

2901924

2901925

2901926

2901927

2901928

2901929

3003006

3092397

3092398

3092399

3092401

3092405

3511256

8117995

8177858

8179174

A_23_P387057

A_23_P81912

GE61339

GO:0000166

GO:0000226

GO:0000278

GO:0002376

GO:0003824

GO:0003924

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005641

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0007059

GO:0015630

GO:0016787

GO:0019904

GO:0030154

GO:0030705

GO:0031410

GO:0031625

GO:0032794

GO:0032991

GO:0034330

GO:0035578

GO:0036464

GO:0042267

GO:0042288

GO:0043226

GO:0044297

GO:0044877

GO:0045121

GO:0045171

GO:0046872

GO:0048856

GO:0050807

GO:0051225

GO:0051301

GO:0070062

GO:0071895

GO:0072686

GO:0098542

HMNXSV003022026

Hs.179661.5.A1_3p_at

ILMN_1665583

ILMN_1704750

ILMN_2101885

J00314_at

PH_hs_0029875

TC06000347.hg

TC6_apd_hap1000029.hg

TC6_cox_hap2000045.hg

TC6_dbb_hap3000038.hg

TC6_mann_hap4000040.hg

TC6_mcf_hap5000032.hg

TC6_qbl_hap6000038.hg

TC6_ssto_hap7000038.hg

V00599_s_at

g4929137_3p_s_at

Participates

as a component of

TUBB:colchicine [cytosol] (Homo sapiens)

as an input of

TUBB binds colchicine (Homo sapiens)

Other forms of this molecule

TUBB [azurophil granule lumen]

TUBB [extracellular region]

Cross References

RefSeq

NP_001280145.1, NP_001280144.1, NP_821133.1, NP_001280142.1, NP_001280143.1, NP_001280141.1

Guide to Pharmacology - Targets

2640

OpenTargets

ENSG00000196230

GeneCards

P07437

HPA

ENSG00000196230-TUBB

Ensembl

ENST00000419792, ENSG00000235067, ENSG00000232421, ENST00000327892, ENST00000432462, ENSP00000401317, ENSG00000229684, ENSP00000373058, ENSG00000232575, ENST00000422650, ENST00000422674, ENST00000436628, ENSP00000410829, ENST00000421473, ENSP00000406811, ENSP00000400663, ENST00000383564, ENSP00000339001, ENSG00000224156, ENSP00000399155, ENSP00000410071, ENSG00000196230, ENSG00000227739, ENSG00000183311

PRO

P07437

Pharos - Targets

P07437

Orphanet

23571

HMDB Protein

HMDBP08048

PDB

6QUY, 6QVJ, 8BPO, 3QO0, 3QNZ, 7TRG, 6QVE, 6QUS, 7X0S, 8V2I, 7TUB, 7TTN, 5N5N, 7TTT, 6I2I

Interactors (45)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.744	6
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.666	4
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.666	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	5
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.564	3
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581) DLST [mitochondrial matrix] (R-HSA-6792574)	0.556	3
UniProt:Q8TDX7 NEK7	2	p-S195-NEK7 [cytosol] (R-HSA-2984246) NEK7 [cytosol] (R-HSA-2530599)	0.556	3
UniProt:I6L9F6 I6L9F6			0.556	3
UniProt:Q03403 TFF2			0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) 2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697)	0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q8N448 LNX2			0.553	2
UniProt:Q71U36 TUBA1A	9	AcK-TUBA1A [cytosol] (R-HSA-5618312) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) TUBA1A(1-450) [cytosol] (R-HSA-8955577) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433)	0.547	5
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.547	4
UniProt:O14939 PLD2	2	PLD2 [plasma membrane] (R-HSA-2029075) PLD2 [endoplasmic reticulum membrane] (R-HSA-1498791)	0.527	3
UniProt:Q8N0Z6 TTC5	3	TTC5 [nucleoplasm] (R-HSA-6804264) p-S203-TTC5 [nucleoplasm] (R-HSA-6804261) p-S203,S221-TTC5 [nucleoplasm] (R-HSA-6804259)	0.527	2
UniProt:Q6R327 RICTOR	1	RICTOR [cytosol] (R-HSA-198632)	0.527	2
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [cytosol] (R-HSA-390464)	0.527	2
UniProt:P55789 GFER	1	GFER [mitochondrial intermembrane space] (R-HSA-1252051)	0.527	2
UniProt:Q77M19 Q77M19			0.527	2
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:P62829 RPL23	1	RPL23 [cytosol] (R-HSA-72430)	0.527	3
UniProt:Q9NUJ3 T11L1			0.527	3
UniProt:P04350 TUBB4A	6	TUBB4A [cytosol] (R-HSA-190588) TUBB4A [axonemal microtubule] (R-HSA-5610435) Polyglutamyl-TUBB4A [cytosol] (R-HSA-8867425) Polyglycyl-TUBB4A [cytosol] (R-HSA-8867397) TUBB4A unfolded [cytosol] (R-HSA-392778) TUBB4A folding intermediate [cytosol] (R-HSA-392789)	0.527	2
UniProt:Q05322 VP24			0.527	3
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.527	3
UniProt:Q3ZCM7 TUBB8	3	Polyglycyl-TUBB8 [cytosol] (R-HSA-8867423) Polyglutamyl-TUBB8 [cytosol] (R-HSA-8867387) TUBB8 [cytosol] (R-HSA-6805243)	0.527	3
UniProt:Q13509 TUBB3	6	TUBB3 folding intermediate [cytosol] (R-HSA-392806) TUBB3 unfolded [cytosol] (R-HSA-392770) Polyglycyl-TUBB3 [cytosol] (R-HSA-8867372) Polyglutamyl-TUBB3 [cytosol] (R-HSA-8867464) TUBB3 [axonemal microtubule] (R-HSA-5610436) TUBB3 [cytosol] (R-HSA-190532)	0.527	3
UniProt:P07919 UQCRH	1	UQCRH [mitochondrial inner membrane] (R-HSA-164286)	0.527	2
UniProt:Q9NWK9 BCD1			0.527	2
UniProt:Q9BQE3 TUBA1C	9	AcK-TUBA1C [cytosol] (R-HSA-5618314) Ac K40 TUBA1C [axonemal microtubule] (R-HSA-5624856) TUBA1C folding intermediate [cytosol] (R-HSA-392798) TUBA1C unfolded [cytosol] (R-HSA-392772) L-isoglutamyl polyglycyl-TUBA1C [cytosol] (R-HSA-8867405) Polyglutamyl-TUBA1C [cytosol] (R-HSA-8867401) TUBA1C(1-448) [cytosol] (R-HSA-8955579) TUBA1C [axonemal microtubule] (R-HSA-5610439) TUBA1C [cytosol] (R-HSA-190590)	0.527	2
UniProt:Q13885 TUBB2A	6	TUBB2A folding intermediate [cytosol] (R-HSA-392802) TUBB2A unfolded [cytosol] (R-HSA-392776) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) TUBB2A [axonemal microtubule] (R-HSA-5610431) TUBB2A [cytosol] (R-HSA-191699)	0.527	3
UniProt:P54764 EPHA4	2	EPHA4 [plasma membrane] (R-HSA-2682325) p-Y596,Y602-EPHA4 [plasma membrane] (R-HSA-3928352)	0.527	2
UniProt:P36404 ARL2	2	ARL2 [cytosol] (R-HSA-5216230) ARL2 [mitochondrial matrix] (R-HSA-5250216)	0.527	3
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2
UniProt:P51114 FXR1	2	FXR1(2-784)-BRAF(381-766) fusion [cytosol] (R-HSA-6802326) FXR1(2-784)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802530)	0.508	2
UniProt:Q8AZK7 EBNA5			0.499	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:Q00005 2ABB			0.462	2
UniProt:A0A096LP01 SIM26			0.462	2

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