Reactome | PalmS-ESR2 [cytosol]

PalmS-ESR2 [cytosol]

Stable Identifier

R-HSA-9020979

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Estrogen receptor beta, ESR2_HUMAN

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External Reference Information

External Reference

UniProt:Q92731 ESR2

Gene Names

ESR2, ESTRB, NR3A2

Chain

chain:1-530

Reference Genes

BioGPS Gene:2100 ESR2

COSMIC (genes):ESR2 ESR2

CTD Gene:2100 ESR2

dbSNP Gene:2100 ESR2

ENSEMBL:ENSG00000140009 ESR2

HGNC:3468 ESR2

KEGG:hsa:2100 ESR2

Monarch:2100 ESR2

NCBI Gene:2100 ESR2

OMIM:601663 ESR2

UCSC:Q92731 ESR2

Reference Transcript

Participates

as a candidate of

PalmS-ESRs [cytosol] (Homo sapiens)

Other forms of this molecule

ESR2 [cytosol]

ESR2 [nucleoplasm]

Me-PalmS-ESR2 [plasma membrane]

PalmS-ESR2 [plasma membrane]

Inferred To

Esr2 [cytosol] (Mus musculus)

Esr2 [cytosol] (Rattus norvegicus)

knrl [cytosol] (Drosophila melanogaster)

ESR2 [cytosol] (Bos taurus)

ESR2 [cytosol] (Canis familiaris)

ESR2 [cytosol] (Sus scrofa)

esr2 [cytosol] (Xenopus tropicalis)

ERR [cytosol] (Drosophila melanogaster)

Homologues of PalmS-ESR2 [cytosol] (Drosophila melanogaster)

PalmS-ESR2 [cytosol] (Gallus gallus)

eg [cytosol] (Drosophila melanogaster)

esr2a [cytosol] (Danio rerio)

kni [cytosol] (Drosophila melanogaster)

Modified Residues

Name

S-palmitoyl-L-cysteine at 399

Coordinate

399

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Cross References

RefSeq

NP_001035365.1, NP_001201831.1, XP_016876571.1, XP_016876569.1, XP_016876573.1, XP_016876570.1, XP_016876568.1, XP_016876572.1, NP_001258806.1, NP_001258805.1, NP_001278652.1, NP_001428.1, NP_001278641.1

Guide to Pharmacology - Targets

621

OpenTargets

ENSG00000140009

ENSEMBL

ENST00000353772, ENSG00000140009, ENST00000553796, ENSP00000267525, ENSP00000335551, ENSP00000450488, ENST00000554572, ENST00000341099, ENST00000555278, ENSP00000343925, ENSP00000345616, ENSP00000452426, ENSP00000450699, ENST00000344288, ENST00000267525, ENSP00000451582, ENST00000557772, ENSP00000351412, ENST00000358599

ZINC - FDA approved

ESR2_HUMAN

ZINC - Substances

ESR2_HUMAN

ZINC - Biogenic

ESR2_HUMAN

ZINC target

Q92731

PRO

Q92731

PDB

4J26, 7XWQ, 7XWR, 3OMO, 3OMP, 2YLY, 1U3S, 3OLL, 1ZAF, 1U3R, 2I0G, 2GIU, 1YY4, 1U3Q, 2JJ3, 2Z4B, 3OLS, 2FSZ, 1NDE, 1X7J, 7XVZ, 2NV7, 7XVY, 7XWP, 5TOA, 1L2J, 1YYE, 4J24, 3OMQ, 1QKM, 2QTU, 1X76, 2YJD, 1U9E, 1X7B, 4ZI1, 1X78

ZINC - Investigational

ESR2_HUMAN

ZINC - Metabolites

ESR2_HUMAN

GeneCards

ESR2

HPA

ENSG00000140009-ESR2

Pharos - Targets

Q92731

Orphanet

ESR2

ZINC - Predictions - Purchasable

ESR2_HUMAN

HMDB Protein

HMDBP00450

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29279 CTGF	1	CTGF [extracellular region] (R-HSA-561148)	0.626	5
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.597	3
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.597	6
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.591	4
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.532	3
UniProt:Q99460 PSMD1	4	PSMD1 [cytosol] (R-HSA-68786) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [extracellular region] (R-HSA-6806194)	0.527	2
UniProt:P20930 FLG	2	FLG(?-?) [cytosol] (R-HSA-6810859) FLG(1-4061) [cytosol] (R-HSA-8849818)	0.527	2
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.527	5
UniProt:Q15149 PLEC	3	PLEC [cytosol] (R-HSA-201575) PLEC(1-2395) [cytosol] (R-HSA-350638) PLEC(2396-4684) [cytosol] (R-HSA-350618)	0.527	2
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.527	3
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.527	3
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.527	5
UniProt:P12814 ACTN1	3	ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722) ACTN1 [cytosol] (R-HSA-354096)	0.527	2
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.527	2
UniProt:Q13243 SRSF5	1	SRSF5 [nucleoplasm] (R-HSA-72028)	0.527	2
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.527	2
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.508	4
UniProt:Q60974 Ncor1	3	Ncor1 [cytosol] (R-MMU-1253324) Ncor1 [nucleoplasm] (R-MMU-442459) Ncor1 [nucleoplasm] (R-MMU-442501)	0.508	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.499	8
UniProt:Q9Y4W2 LAS1L	1	LAS1L [nucleoplasm] (R-HSA-6791521)	0.462	2
UniProt:P48552 NRIP1	2	NRIP1 [nucleoplasm] (R-HSA-4086031) monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057)	0.462	2
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.462	2
UniProt:P62277 RPS13	2	RPS13 [cytosol] (R-HSA-72331) RPS13 [nucleoplasm] (R-HSA-6791198)	0.462	2
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.462	2
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.462	2
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(200-270) [extracellular region] (R-HSA-976940)	0.462	2
UniProt:P50416 CPT1A	1	CPT1A [mitochondrial outer membrane] (R-HSA-400161)	0.462	2
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.462	2
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.462	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.462	2
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.462	2
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.462	2
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.462	2
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.462	2
UniProt:O60264 SMARCA5	1	SMARCA5 [nucleoplasm] (R-HSA-417140)	0.462	2
UniProt:P46781 RPS9	2	RPS9 [cytosol] (R-HSA-72387) RPS9 [nucleoplasm] (R-HSA-6790663)	0.462	2
UniProt:Q71UM5 RPS27L	2	RPS27L [nucleoplasm] (R-HSA-6791197) RPS27L [cytosol] (R-HSA-8868849)	0.462	2
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.462	2