Reactome | PalmS-ESRs:CAVs translocate to plasma membrane

PalmS-ESRs:CAVs translocate to plasma membrane

Stable Identifier

R-HSA-9021079

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PalmS-ESRs:CAVs translocate to plasma membrane

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Palmitoylation of estrogen receptors promotes their interaction with caveolin (CAV), which is required for their translocation to the plasma membrane where they function in rapid, transcription-independent signaling (Chambliss et al, 2002; Razandi et al, 2003; Acconcia et al, 2004; Pedram et al, 2007; Razandi et al, 2010; Pedram et al, 2012; reviewed in Schwartz et al, 2016). Approximately 5-15% of total cellular estrogen receptor is at the plasma membrane where it is enriched in caveolae (Pedram et al, 2006; Marino et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
11981029	ERbeta has nongenomic action in caveolae Mendelsohn, ME, Yuhanna, IS, Chambliss, KL, Shaul, PW, Anderson, RG	Mol. Endocrinol.	2002
15033483	S-palmitoylation modulates human estrogen receptor-alpha functions Marino, M, Fabozzi, G, Ascenzi, P, Acconcia, F, Visca, P	Biochem. Biophys. Res. Commun.	2004
12588983	Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane Webb, P, Alton, G, Levin, ER, Razandi, M, Ghonshani, S, Pedram, A	Mol. Cell. Biol.	2003
17535799	A conserved mechanism for steroid receptor translocation to the plasma membrane Kim, JK, Hughes, CC, Levin, ER, Razandi, M, Sainson, RC, Pedram, A	J. Biol. Chem.	2007
16274718	S-palmitoylation modulates estrogen receptor alpha localization and functions Marino, M, Ascenzi, P, Acconcia, F	Steroids	2006
22031296	DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors Levin, ER, Razandi, M, Deschenes, RJ, Pedram, A	Mol. Biol. Cell	2012
16645038	Nature of functional estrogen receptors at the plasma membrane Levin, ER, Razandi, M, Pedram, A	Mol. Endocrinol.	2006
20439495	Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane Levin, ER, Razandi, M, Pedram, A	Mol. Cell. Biol.	2010
27288742	Rapid steroid hormone actions via membrane receptors Verma, A, Schwartz, Z, Bivens, CB, Schwartz, N, Boyan, BD	Biochim. Biophys. Acta	2016