Reactome | Estrogen stimulates dimerization of plasma membrane estrogen receptors

Estrogen stimulates dimerization of plasma membrane estrogen receptors

Stable Identifier

R-HSA-9021170

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Estrogen stimulates dimerization of plasma membrane estrogen receptors

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Plasma membrane-localized estrogen receptors signal as dimers, and dimerization is promoted by stimulation with estrogen (Razandi et al, 2004). Because palmitoylation of cytoplasmic estrogen receptors occurs on the monomeric form, estrogen (ESTG) stimulation restricts both the amount of palmitoylated receptor and its localization at the plasma membrane (Acconcia et al, 2005; Razandi et al, 2010; Pedram et al, 2012). This may serve to limit the extent of the rapid response to estrogen stimulation.

Literature References

PubMed ID	Title	Journal	Year
22031296	DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors Levin, ER, Razandi, M, Deschenes, RJ, Pedram, A	Mol. Biol. Cell	2012
15231873	Plasma membrane estrogen receptors exist and functions as dimers Levin, ER, Merchenthaler, I, Razandi, M, Greene, GL, Pedram, A	Mol. Endocrinol.	2004
20439495	Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane Levin, ER, Razandi, M, Pedram, A	Mol. Cell. Biol.	2010
15496458	Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol Marino, M, Bocedi, A, Trentalance, A, Ascenzi, P, Acconcia, F, Visca, P, Tomasi, V, Spisni, E	Mol. Biol. Cell	2005