Estrogen stimulates dimerization of plasma membrane estrogen receptors

Stable Identifier
R-HSA-9021170
Type
Reaction [binding]
Species
Homo sapiens
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Plasma membrane-localized estrogen receptors signal as dimers, and dimerization is promoted by stimulation with estrogen (Razandi et al, 2004). Because palmitoylation of cytoplasmic estrogen receptors occurs on the monomeric form, estrogen (ESTG) stimulation restricts both the amount of palmitoylated receptor and its localization at the plasma membrane (Acconcia et al, 2005; Razandi et al, 2010; Pedram et al, 2012). This may serve to limit the extent of the rapid response to estrogen stimulation.

Literature References
PubMed ID Title Journal Year
22031296 DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors

Levin, ER, Razandi, M, Deschenes, RJ, Pedram, A

Mol. Biol. Cell 2012
15496458 Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol

Marino, M, Bocedi, A, Trentalance, A, Ascenzi, P, Acconcia, F, Visca, P, Tomasi, V, Spisni, E

Mol. Biol. Cell 2005
15231873 Plasma membrane estrogen receptors exist and functions as dimers

Levin, ER, Merchenthaler, I, Razandi, M, Greene, GL, Pedram, A

Mol. Endocrinol. 2004
20439495 Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane

Levin, ER, Razandi, M, Pedram, A

Mol. Cell. Biol. 2010
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