NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter

Stable Identifier
R-HSA-9021480
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter
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The WWC1 (Kibra) gene promoter region contains two RBPJ-binding sites, one on the sense strand and one on the antisense strand. The NOTCH3 coactivator complex binds to the RBPJ-binding site on the antisense strand (Zhang et al. 2016).
Literature References
PubMed ID Title Journal Year
27841855 Notch3 inhibits epithelial-mesenchymal transition by activating Kibra-mediated Hippo/YAP signaling in breast cancer epithelial cells

Li, Y, Zhang, X, Chen, M, Liu, X, Ye, X, Luo, J, Zhang, GJ, Xiao, W

Oncogenesis 2016
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Output
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Event Information
Go Biological Process
positive regulation of transcription of Notch receptor target (0007221)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-09-18)
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