G-proteins dissociate from plasma-membrane estrogen receptors

Stable Identifier
Reaction [dissociation]
Homo sapiens
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Estrogen-stimulation promotes dissociation of the G protein subunits and stimulates downstream signaling through SRC and PI3K (Castoria et al, 2001; Castoria et al, 2012; Wyckoff et al, 2001).

Literature References
PubMed ID Title Journal Year
22266855 Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells

Auricchio, F, Migliaccio, A, Castoria, G, De Rosa, C, Barone, MV, de Falco, A, Giraldi, T, Abbondanza, C, Giovannelli, P, Lombardi, M

Oncogene 2012
11689445 PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

Auricchio, F, Fiorentino, R, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L

EMBO J. 2001
11369763 Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i)

Mendelsohn, ME, Yuhanna, IS, Mumby, SM, Mineo, C, Wyckoff, MH, Chambliss, KL, Shaul, PW

J. Biol. Chem. 2001
Orthologous Events
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