G-proteins dissociate from plasma-membrane estrogen receptors

Stable Identifier
R-HSA-9021600
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Estrogen-stimulation promotes dissociation of the G protein subunits and stimulates downstream signaling through SRC and PI3K (Castoria et al, 2001; Castoria et al, 2012; Wyckoff et al, 2001).
Literature References
PubMed ID Title Journal Year
11369763 Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i)

Mendelsohn, ME, Yuhanna, IS, Mumby, SM, Mineo, C, Wyckoff, MH, Chambliss, KL, Shaul, PW

J. Biol. Chem. 2001
22266855 Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells

Auricchio, F, Migliaccio, A, Castoria, G, De Rosa, C, Barone, MV, de Falco, A, Giraldi, T, Abbondanza, C, Giovannelli, P, Lombardi, M

Oncogene 2012
11689445 PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

Auricchio, F, Fiorentino, R, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L

EMBO J. 2001
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!