Reactome | EPOR-associated PI3K phosphorylates PIP2 to PIP3

EPOR-associated PI3K phosphorylates PIP2 to PIP3

Stable Identifier

R-HSA-9021627

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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EPOR-associated PI3K phosphorylates PIP2 to PIP3

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Phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) associated with EPOR phosphorylates phosphatidylinositol 4,5-bisphosphate to yield phosphatidyl 3,4,5-trisphosphate (Kubota et al. 2001, Schmidt et al. 2004). PI3K binds the phosphorylated EPOR directly or indirectly via phosphorylated IRS2 or phosphorylated GAB1 (Bouscary et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12506011	Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation Claessens, YE, Mayeux, P, Fontenay-Roupie, M, Bouscary, D, Pene, F, Lacombe, C, Muller, O, Chrétien, S, Gisselbrecht, S	Blood	2003
11598010	Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase Kubota, Y, Kitanaka, A, Ishida, T, Kamano, H, Ohnishi, H, Waki, M, Tanaka, T, Okutani, Y	EMBO J.	2001
15149544	PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors Schmidt, EK, Feller, SM, Fichelson, S	BMC Biol.	2004