Reactome | USF1 [nucleoplasm]

USF1 [nucleoplasm]

Stable Identifier

R-HSA-9023562

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Upstream stimulatory factor 1, USF1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P13010 XRCC5

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External Reference Information

External Reference

UniProt:P22415 USF1

Gene Names

USF1, BHLHB11, USF

Chain

chain:1-310

Reference Genes

BioGPS Gene:7391 USF1

COSMIC (genes):USF1 USF1

CTD Gene:7391 USF1

dbSNP Gene:7391 USF1

ENSEMBL:ENSG00000158773 USF1

ENSEMBL_homo_sapiens_GENE:ENSG00000158773.14 USF1

HGNC:12593 USF1

KEGG Gene (Homo sapiens):7391 USF1

Monarch:7391 USF1

NCBI Gene:7391 USF1

OMIM:191523 USF1

UCSC:P22415 USF1

Reference Transcript

Other Identifiers

11732958_at

16695517

231768_PM_at

231768_at

2440519

2440520

2440521

2440522

2440524

2440525

2440527

2440529

2440530

2440531

2440533

2440534

2440535

2440536

2440537

2440539

2440541

2440542

2440546

7391

7921738

A_23_P23646

GE62464

GE79273

GO:0000430

GO:0000432

GO:0000785

GO:0000978

GO:0000981

GO:0001666

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005794

GO:0006351

GO:0006355

GO:0006357

GO:0009411

GO:0019086

GO:0019899

GO:0019901

GO:0032869

GO:0042060

GO:0042593

GO:0042802

GO:0042803

GO:0042826

GO:0043226

GO:0043425

GO:0043565

GO:0044877

GO:0045893

GO:0045944

GO:0045990

GO:0046982

GO:0046983

GO:0051918

GO:0055088

GO:0140110

GO:1990837

HMNXSV003032477

Hs.247842.0.S2_3p_at

ILMN_1777982

ILMN_2353240

PH_hs_0018550

TC01003413.hg

X55666_at

Participates

as a component of

as an input of

HATs and coactivators are recruited to the CTSD gene (Homo sapiens)

Other forms of this molecule

pT153 USF1 [nucleoplasm]

Inferred To

usf1 [nucleoplasm] (Danio rerio)

usf1 [nucleoplasm] (Xenopus tropicalis)

Usf [nucleoplasm] (Drosophila melanogaster)

USF1 [nucleoplasm] (Bos taurus)

USF1 [nucleoplasm] (Canis familiaris)

USF1 [nucleoplasm] (Gallus gallus)

USF1 [nucleoplasm] (Sus scrofa)

Usf1 [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_009053.1, NP_001263302.1, NP_996888.1

OpenTargets

ENSG00000158773

HPA

ENSG00000158773-USF1

GeneCards

P22415

Ensembl

ENSP00000357000, ENSP00000356999, ENST00000368020, ENST00000368021, ENSG00000158773

PRO

P22415

Pharos - Targets

P22415

PDB

1AN4

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15407 FOSL1	1	FOSL1 [nucleoplasm] (R-HSA-9620405)	0.782	7
UniProt:Q15853 USF2	1	USF2 [nucleoplasm] (R-HSA-9023564)	0.708	5
UniProt:P22415 USF1	2	USF1 [nucleoplasm] (R-HSA-9023562) pT153 USF1 [nucleoplasm] (R-HSA-9855887)	0.666	4
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.623	5
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.623	5
UniProt:Q02880 TOP2B	2	monoSUMO1-K-TOP2B [nucleoplasm] (R-HSA-4641297) TOP2B [nucleoplasm] (R-HSA-4641359)	0.558	3
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.558	3
UniProt:P13010 XRCC5	4	XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [nucleoplasm] (R-HSA-58274)	0.558	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:P57077-4 MAP3K7CL			0.556	3
UniProt:P28838 AMPL			0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:Q6FG41 Q6FG41			0.556	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.527	3
UniProt:Q15853-2 USF2			0.527	2
UniProt:Q9NR55 BATF3			0.527	2
IntAct:EBI-9515373 MLP-DSDNA PROBE			0.524	7
UniProt:Q9UKV0 HDAC9	1	HDAC9 [nucleoplasm] (R-HSA-3004554)	0.462	3
UniProt:P12956 XRCC6	5	XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272)	0.462	2

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