Butyrylcholinesterase hydrolyzes acyl Ghrelin

Stable Identifier
Reaction [transition]
Homo sapiens
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The majority of circulating ghrelin is not acylated (des-acyl ghrelin). Acyl ghrelin can be deacylated in the bloodstream by butyrylcholinesterase and platelet-activating factor acetylhydrolase, which are associated with circulating lipids. Other enzymes may also have this capability. It is unknown if a portion of des-acyl ghrelin in the bloodstream is generated by direct synthesis and secretion.

Literature References
PubMed ID Title Journal Year
19280057 Ghrelin fluctuation, what determines its production?

Yin, X, Li, Y, Zhang, W, An, W, Xu, G

Acta Biochim Biophys Sin (Shanghai) 2009
17289852 Ghrelin interacts with human plasma lipoproteins

Carpentier, Y, Delporte, C, Hacquebard, M, De Vriese, C, Gregoire, F

Endocrinology 2007
18396350 Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle

Soares, JB, Leite-Moreira, AF

Peptides 2008
15256494 Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites

Delporte, C, Robberecht, P, Lema-Kisoka, R, De Vriese, C, Waelbroeck, M, Gregoire, F

Endocrinology 2004
Catalyst Activity

hydrolase activity, acting on ester bonds of Butyrylcholinesterase [extracellular region]

Orthologous Events
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