Dipeptidyl Peptidase IV (DPP4) cleaves 2 amino acids from the N-terminus of GIP, inactivating it. DPP4 determines the half life of GIP in the bloodstream. It is unknown if the soluble form of DPP4, the membrane-bound form, or both catalyze the cleavage of GIP.
Gorrell, MD
Schmidt, WE, Mentlein, R, Gallwitz, B
serine-type endopeptidase activity of DPP4(1-766) [plasma membrane]
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