DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)

Stable Identifier
R-HSA-9023627
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)
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Dipeptidyl Peptidase IV (DPP4) cleaves 2 amino acids from the N-terminus of GIP, inactivating it. DPP4 determines the half life of GIP in the bloodstream. It is unknown if the soluble form of DPP4, the membrane-bound form, or both catalyze the cleavage of GIP.

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Catalyst Activity

serine-type endopeptidase activity of DPP4(1-766) [plasma membrane]

Physical Entity
DPP4(1-766) [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)
DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Danio rerio)
DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Gallus gallus)
DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)
DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)
Authored
May, B  (2009-05-19)
Reviewed
Bloom, SR  (2010-06-25)
Created
May, B  (2017-09-28)
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