Estrogen-stimulated expression of CTSD depends on the cyclic recruitment of DNA-binding and other transcriptional activators. Binding sites for the DNA-binding transcriptional activators SP1, USF1 and 2 have been identified in the proximal CTSD promoter (Xing and Archer, 1998; Wang et al, 1998; Krishnan et al, 1994; Wang et al, 2001; reviewed in Safe, 2000). Other early factors that contribute to estrogen-dependent CTSD expression include the co-activator NCOA3, EP300 and MED1, a component of the mediator complex. These factors contribute to the formation of transcriptionally active chromatin and to the recruitment of RNA polymerase II (Shang et al, 2000; Bretschneider et al, 2008). Note that although these factors are shown at the CTSD promoter simultaneously, they have not all been demonstrated to form part of a single complex on an individual CTSD promoter.
Safe, S, Hoivik, D, Pollenz, R, Wang, F
Archer, TK, Xing, W
Hu, X, Brown, M, DiRenzo, J, Shang, Y, Lazar, MA
Safe, S
Krishnan, V, Wang, X, Safe, S
Reid, G, Kangaspeska, S, Bretschneider, N, Seifert, M, Gannon, F, Denger, S
Wang, F, Samudio, I, Safe, S
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